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Showing 1–3 of 3 results

Advanced filters: Author: Rafik Salama Clear advanced filters

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

Genome-wide association studies have identified multiple loci associated with the risk of developing renal cancer. Here, the authors show that one of these loci generates open chromatin, which enhances the binding of HIF and HIF-mediated transactivation ofMYC.

Steffen Grampp
James L. Platt
Johannes Schödel
ResearchOpen Access24 Oct 2016
Nature Communications

Volume: 7, P: 1-11
NOTCH1 mediates a switch between two distinct secretomes during senescence

Hoare et al. find that NOTCH1 regulates the switch between two distinct senescence-associated secretomes—the TGF-β pathway and pro-inflammatory cytokines—and that its inhibition promotes clearance of oncogene-induced senescent liver cells.

Matthew Hoare
Yoko Ito
Masashi Narita
Research15 Aug 2016
Nature Cell Biology

Volume: 18, P: 979-992
Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer

Virginia Schmid
Veronique N. Lafleur
David R. Mole
ResearchOpen Access10 Dec 2019
Scientific Reports

Volume: 9, P: 1-17