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Showing 1–4 of 4 results

Advanced filters: Author: Raghu R. Chivukula Clear advanced filters

Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation

Max L. Valenstein
Pranav V. Lalgudi
David M. Sabatini
Research08 Jan 2025
Nature

Volume: 637, P: E11-E14
Author Correction: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance

Raghu R. Chivukula
Daniel T. Montoro
David M. Sabatini
Amendments and Corrections29 Jan 2020
Nature Medicine

Volume: 26, P: 300
Structural basis for the dynamic regulation of mTORC1 by amino acids

Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for cellular growth.

Max L. Valenstein
Maximilian Wranik
Kacper B. Rogala
ResearchOpen Access20 Aug 2025
Nature

Volume: 646, P: 493-500
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance

Inactivating mutations in a protein kinase, NEK10, cause a genetic bronchiectasis syndrome in humans that is characterized by short motile cilia and impaired mucociliary transport.

Raghu R. Chivukula
Daniel T. Montoro
David M. Sabatini
Research20 Jan 2020
Nature Medicine

Volume: 26, P: 244-251