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Showing 1–7 of 7 results
Advanced filters: Author: Rahul Chadda Clear advanced filters

  • Static protein structures can capture the association of lipids, but it is unclear whether the association is due to lipids acting as long-lived ligands or the solvation of preferred lipids around the protein. A computational-experimental framework has now shown that for the protein CLC-ec1, it is the change in lipid solvation energies that drives dimerization, with preferred lipids around the protein modulating this driving force.

    • Nathan Bernhardt
    • Tugba N. Ozturk
    • José D. Faraldo-Gómez
    ResearchOpen Access
    Nature Chemical Biology
    P: 1-11

  • Mediator proteins such as BRCA2 and Rad52 direct formation of Rad51 filaments in Homologous Recombination. Here, the authors present cryoEM structures of Saccharomyces cerevisiae Rad52 revealing a homodecamer and Rad51 binding to two regions in Rad52.

    • Jaigeeth Deveryshetty
    • Rahul Chadda
    • Edwin Antony
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • The single stranded DNA binding protein RPA coordinates DNA metabolism using multiple protein and DNA interaction domains. Here, the authors show that the chaperone-like protein Rtt105 staples RPA domains to prevent untimely protein interactions.

    • Sahiti Kuppa
    • Jaigeeth Deveryshetty
    • Edwin Antony
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • This study reveals the mechanism by which protons gate a CLC-type Cl−/H+ exchanger. The authors show that pH-dependent concerted structural rearrangements open the H+ pathway, which allosterically enables the Cl− pore opening and ion exchange.

    • Eva Fortea
    • Sangyun Lee
    • Alessio Accardi
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 644-656

  • RPA is a master coordinator of DNA metabolism. Here, authors uncover that RPA is regulated by an Aurora B-signaling circuit that is critical for chromosome segregation in mitosis. Distinct phosphorylation of RPA70 modulates accessibility of RPA domains.

    • Poonam Roshan
    • Sahiti Kuppa
    • Sofia Origanti
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Monitoring new fluorescent ganglioside analogs at a single-molecule level suggests that gangliosides associate dynamically with GPI-anchored protein monomers, transient homodimer rafts, and clustered signaling rafts in a cholesterol-dependent manner.

    • Naoko Komura
    • Kenichi G N Suzuki
    • Makoto Kiso
    Research
    Nature Chemical Biology
    Volume: 12, P: 402-410