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Showing 1–9 of 9 results
Advanced filters: Author: Raj Kumar Manna Clear advanced filters

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Here, authors demonstrate that a peptidomimetic forms membrane channels and transports ions. It induces time-dependent cancer cell death via stabilization of G-quadruplexes and influences complex biological functions.

    • Raj Paul
    • Debasish Dutta
    • Jyotirmayee Dash
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

    • Erola Pairo-Castineira
    • Sara Clohisey
    • J. Kenneth Baillie
    Research
    Nature
    Volume: 591, P: 92-98

  • Catalytic reactions on flexible sheets generate fluid flows that transform the shape of the sheet, which in turn modifies the flow. These complex interactions make computer models vital for designing and harnessing these feedback loops to create soft active matter that autonomously performs self-sustained mechanical work.

    • Abhrajit Laskar
    • Raj Kumar Manna
    • Anna C. Balazs
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 13, P: 1-4

  • Chemically active, flexible sheets convert chemical energy into the flow of the surrounding fluid, which, in turn, transforms the sheet’s shape. This Perspective describes how this feedback produces shape-changing 3D objects, coupled oscillators exhibiting spatiotemporal coordination and the rotation of chemically driven gears.

    • Raj Kumar Manna
    • Abhrajit Laskar
    • Anna C. Balazs
    Reviews
    Nature Reviews Physics
    Volume: 4, P: 125-137