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Showing 1–2 of 2 results
Advanced filters: Author: Rajan Iyyappan Clear advanced filters

  • Gene editing technologies enable precise DNA modifications but remain limited by efficiency, precision of intended edits, and flexibility. Here, authors develop chimeric oligonucleotide-directed and Cas polymerase-based systems that enhance programmable gene correction across cells and embryos.

    • Long T. Nguyen
    • Noah R. Rakestraw
    • Piyush K. Jain
    ResearchOpen Access
    Nature Communications
    P: 1-12

  • Here the authors reveal that late replicating regions emerge from the first cell cycle post-fertilization, associate with the B compartment and nuclear lamina in maternal and paternal genomes. In bovine and mouse embryos, replication timing is set before embryonic genome activation, leading to enhanced fragility in long neuronal genes.

    • Shuangyi Xu
    • Ning Wang
    • Dieter Egli
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12