Chronic ulcerative cholitis contributes to the differentiation of HSPCs toward myelopoiesis in an APE1/Ref-1/HIF-1α/IL-1r1 dependent manner. Blockade of the redox activity of Ref-1 with APX3330 rescues the abnormal HSC function.
- Ramesh Kumar
- Rahul Kanumuri
- Reuben Kapur