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Showing 1–11 of 11 results
Advanced filters: Author: Rajesha Rupaimoole Clear advanced filters

  • Reduced expression of DICER—responsible for the processing of microRNA precursors—was previously linked to poor clinical outcomes in cancer patients. Here, the authors uncover an epigenetic mechanism by which hypoxia suppresses DICER expression and deregulates the miR-200-Zeb1 circuit in breast cancer to promote the tumour phenotype.

    • Twan van den Beucken
    • Elizabeth Koch
    • Bradly G. Wouters
    Research
    Nature Communications
    Volume: 5, P: 1-13

  • MicroRNAs play important roles in the maintenance of cellular homeostasis through the post-transcriptional regulation of gene expression. Here, the authors implicate loss of the miRNA biogenesis factor Drosha and altered miRNA maturation in tumour progression under hypoxic conditions.

    • Rajesha Rupaimoole
    • Sherry Y. Wu
    • Anil K. Sood
    Research
    Nature Communications
    Volume: 5, P: 1-13

  • The microRNA-200 family members have a role in regulating tumour angiogenesis but the underlying mechanism is unclear. In this study, Pecot et al.demonstrate that miR-200 affects angiogenesis by altering endothelial and cancer cell cytokine secretion.

    • Chad V. Pecot
    • Rajesha Rupaimoole
    • Anil K. Sood
    Research
    Nature Communications
    Volume: 4, P: 1-14

  • Ovarian cancer is often accompanied by metastases at the time of diagnosis and has a poor survival rate. In this study, Aslan et al.identify a role for ZNF304 in ovarian cancer metastasis and show that the protein transcriptionally regulates β1 integrin, resulting in a reduction in programmed cell death.

    • Burcu Aslan
    • Paloma Monroig
    • Gabriel Lopez-Berestein
    Research
    Nature Communications
    Volume: 6, P: 1-12

  • The formation of blood vessels in tumours, angiogenesis, is a promising target for therapy. Here, the authors show that microRNA192 has anti-angiogenic functions and negatively regulates EGR1 and HOXB9, and that delivery of this microRNA to tumours in vivocan reduce angiogenesis and tumour growth.

    • Sherry Y. Wu
    • Rajesha Rupaimoole
    • Anil K. Sood
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Short interfering siRNAs—siRNAs—have therapeutic potential in the treatment of disease; however, their delivery to target tissues is difficult. Here, Wu et al. chemically modify siRNAs and show that this improves loading into the siRNA silencing machinery and thus efficacy in eliminating cancer cells in mice.

    • Sherry Y. Wu
    • Xianbin Yang
    • Anil K. Sood
    Research
    Nature Communications
    Volume: 5, P: 1-12

  • In ovarian cancer, metastatic phenotype may impact surgical outcomes. Here, the authors show miR-409-3p regulates FABP4 which can increase metastatic potential of ovarian cancer, and treatment with DOPC nanoliposomes containing either miR-409--3p mimic or FABP4 siRNA inhibits tumor progression in mice.

    • Kshipra M. Gharpure
    • Sunila Pradeep
    • Anil K. Sood
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • MicroRNAs (miRNAs) are small non-coding RNAs that can modulate mRNA expression. Insights into the roles of miRNAs in development and disease have led to the development of new therapeutic approaches that are based on miRNA mimics or agents that inhibit their functions (antimiRs), and the first such approaches have entered the clinic. This Review discusses the role of different miRNAs in cancer and other diseases, and provides an overview of current miRNA therapeutics in the clinic.

    • Rajesha Rupaimoole
    • Frank J. Slack
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 203-222

  • Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway.

    • Monika Haemmerle
    • Morgan L. Taylor
    • Anil K. Sood
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15