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Showing 1–3 of 3 results
Advanced filters: Author: Rajitha Rajeshwar T Clear advanced filters

  • The AT1 GPCR plays an essential role in cardiovascular regulation and may be activated by the peptide AngII as well as membrane stretch. Here, Poudel et al. use molecular simulations to show that membrane-mediated activation produces distinct active-like conformations when compared to activation by AngII.

    • Bharat Poudel
    • Rajitha Rajeshwar T
    • Juan M. Vanegas
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Rotaxanes equipped with actuators hold great potential for developing highly functional molecular machines, and could enhance our ability to study and manipulate biological and artificial membranes. Here, the authors introduce a rotaxane with a ring that features two azobenzene photoswitches, and demonstrate that photoswitching can be used to reversibly modulate lipid bilayer structure. This capability was exploited for the light-triggered release of sulforhodamine B from large unilamellar vesicles.

    • Udyogi N. K. Conthagamage
    • Rajitha Rajeshwar T
    • Víctor García-López
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-11