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Showing 1–5 of 5 results
Advanced filters: Author: Rakhi Desai Clear advanced filters
  • A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

    • Roy Burstein
    • Nathaniel J. Henry
    • Simon I. Hay
    ResearchOpen Access
    Nature
    Volume: 574, P: 353-358
  • Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

    • Joshua S. Weinstock
    • Jayakrishnan Gopakumar
    • Siddhartha Jaiswal
    Research
    Nature
    Volume: 616, P: 755-763
  • Analysis of 97,691 high-coverage human blood DNA-derived whole-genome sequences enabled simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells, indicating that both inherited and acquired mutations are linked to age-related cancers and coronary heart disease.

    • Alexander G. Bick
    • Joshua S. Weinstock
    • Pradeep Natarajan
    Research
    Nature
    Volume: 586, P: 763-768
  • Brain damage induces systemic inflammation, but insights and implication of this induction is still unclear. Here the authors show, using rat and mouse focal cerebral ischemia models, that the damaged brain signals via the VEGF-C/VEFGR3 axis to activate inflammatory responses in the draining cervical lymph nodes to induce systemic inflammation.

    • Elga Esposito
    • Bum Ju Ahn
    • Kazuhide Hayakawa
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13