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Showing 1–14 of 14 results
Advanced filters: Author: Ralf D. Wimmer Clear advanced filters

  • Increased activity of dopamine receptor type-2 (D2R)-expressing cells in the nucleus accumbens of rats during a ‘decision’ period reflects a ‘loss’ outcome of the previous decision, and predicts a subsequent safe choice; by artificially increasing the activity of D2R neurons during the decision period, risk-seeking rats could be converted to risk-avoiding rats.

    • Michael F. Wells
    • Ralf D. Wimmer
    • Michael M. Halassa
    Research
    Nature
    Volume: 532, P: 58-63

  • By examining neural responses from tree shrews performing hierarchical decision tasks with rule reversals, the authors identify a thalamocortical mechanism for regulating cognitive flexibility.

    • Norman H. Lam
    • Arghya Mukherjee
    • Michael M. Halassa
    Research
    Nature
    Volume: 637, P: 127-136

  • A study integrating single-cell RNA-sequencing and electrophysiology data shows that in mouse, the cellular repertoire of the thalamic reticular nucleus is characterized by a transcriptomic gradient defined at its extremes by mutually exclusive expression of Spp1 and Ecel1, providing insights into the organizational principles underlying the divergent functions of this brain region.

    • Yinqing Li
    • Violeta G. Lopez-Huerta
    • Guoping Feng
    Research
    Nature
    Volume: 583, P: 819-824

  • Two different cell types in the mediodorsal thalamus have complementary roles in decision-making, with one type of mediodorsal projection amplifying prefrontal activity under low signal levels and one type suppressing it under high noise levels.

    • Arghya Mukherjee
    • Norman H. Lam
    • Michael M. Halassa
    ResearchOpen Access
    Nature
    Volume: 600, P: 100-104

  • The authors trained mice to attend to or suppress vision based on behavioral context and show, through novel and established techniques, that changes in visual gain rely on tunable feedforward inhibition of visual thalamus via innervating thalamic reticular neurons; these findings introduce a subcortical model of attention in which modality-specific thalamic reticular subnetworks mediate top-down and context-dependent control of sensory selection.

    • Ralf D. Wimmer
    • L. Ian Schmitt
    • Michael M. Halassa
    Research
    Nature
    Volume: 526, P: 705-709

  • The growth rates of freshly formed aerosol particles influence what fraction of these can reach sizes large enough to affect cloud formation and climate. Here, the authors show that the nano-particle growth in a sulphuric acid containing system can be enhanced by the presence of ions or small acid-base clusters.

    • Katrianne Lehtipalo
    • Linda Rondo
    • Markku Kulmala
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Vitamin D and its analogues demonstrated in this study antifibrotic effects in a murine fibrosis model compared to calcitriol. In this study, the hypocalcemic vitamin D analog paricalcitol was superior in respect to side effects and efficacy, indication that such analogs could be considered for the treatment of liver fibrosis.

    • Florian P. Reiter
    • Liangtao Ye
    • Gerald Denk
    Research
    Laboratory Investigation
    Volume: 99, P: 1906-1917