Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–18 of 18 results
Advanced filters: Author: Ralf Herwig Clear advanced filters

  • The temporal regulation of intracellular insulin signaling is not well studied. Here the authors conducted a time-resolved analysis of the global insulin-regulated phosphoproteome in human muscle cells, revealing synchronized signaling pathways for propagating information to insulin effector sites.

    • Michael Turewicz
    • Christine Skagen
    • Hadi Al-Hasani
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • This report from the 1000 Genomes Project describes the genomes of 1,092 individuals from 14 human populations, providing a resource for common and low-frequency variant analysis in individuals from diverse populations; hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites, can be found in each individual.

    • Gil A. McVean
    • David M. Altshuler (Co-Chair)
    • Gil A. McVean
    ResearchOpen Access
    Nature
    Volume: 491, P: 56-65

  • Results for the final phase of the 1000 Genomes Project are presented including whole-genome sequencing, targeted exome sequencing, and genotyping on high-density SNP arrays for 2,504 individuals across 26 populations, providing a global reference data set to support biomedical genetics.

    • Adam Auton
    • Gonçalo R. Abecasis
    • Gonçalo R. Abecasis
    ResearchOpen Access
    Nature
    Volume: 526, P: 68-74

  • STAT3 is an intracellular transducer of cytokine signals that cooperates with Ras in tumour formation and is often activated in lung cancer. Here the authors show that STAT3 acts as a tumour suppressor in a mouse model of Kras-driven lung adenocarcinoma.

    • Beatrice Grabner
    • Daniel Schramek
    • Emilio Casanova
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-14

  • The goal of the 1000 Genomes Project is to provide in-depth information on variation in human genome sequences. In the pilot phase reported here, different strategies for genome-wide sequencing, using high-throughput sequencing platforms, were developed and compared. The resulting data set includes more than 95% of the currently accessible variants found in any individual, and can be used to inform association and functional studies.

    • Richard M. Durbin
    • David Altshuler (Co-Chair)
    • Gil A. McVean
    ResearchOpen Access
    Nature
    Volume: 467, P: 1061-1073

  • The heterogeneity of colorectal cancer has important clinical and therapeutic implications. Here the authors analysed the responses of a large biobank of organoids and xenografts derived from colorectal patients to a panel of clinically relevant therapeutic agents to identify genes signatures associated with drug response.

    • Moritz Schütte
    • Thomas Risch
    • Marie-Laure Yaspo
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19

  • Dysregulation of centrosome size and number is frequently associated with cancer. Fogeron et al. construct a protein-interaction network to identify proteins that are relevant for centrosome abnormalities in cancer, and show that deregulation of LGALS3BP affects centrosomal biogenesis.

    • Marie-Laure Fogeron
    • Hannah Müller
    • Bodo M.H. Lange
    Research
    Nature Communications
    Volume: 4, P: 1-14

  • 1000 Genomes imputation can increase the power of genome-wide association studies to detect genetic variants associated with human traits and diseases. Here, the authors develop a method to integrate and analyse low-coverage sequence data and SNP array data, and show that it improves imputation performance.

    • Olivier Delaneau
    • Jonathan Marchini
    • Leena Peltonenz
    Research
    Nature Communications
    Volume: 5, P: 1-9

  • This Registered Report presents the results of the Long-read RNA-Seq Genome Annotation Assessment Project, which is a community effort for benchmarking long-read methods for transcriptome analyses, including transcript isoform detection, quantification and de novo transcript detection.

    • Francisco J. Pardo-Palacios
    • Dingjie Wang
    • Angela N. Brooks
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 1349-1363

  • Using a network propagation approach with integrated multi-omic data, Selevsek et al. develop a reproducible workflow for identifying drug toxicity effects in cellular systems. This is demonstrated with the analysis of anthracycline cardiotoxicity in cardiac microtissues under the effect of multiple drugs.

    • Nathalie Selevsek
    • Florian Caiment
    • Jos Kleinjans
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-15

  • The IDG-DREAM Challenge carried out crowdsourced benchmarking of predictive algorithms for kinase inhibitor activities on unpublished data. This study provides a resource to compare emerging algorithms and prioritize new kinase activities to accelerate drug discovery and repurposing efforts.

    • Anna Cichońska
    • Balaguru Ravikumar
    • Tero Aittokallio
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • ConsensusPathDB combines molecular interaction data from multiple sources and provides a web interface to vizualize these data. This can be used to build interaction networks and to perform enrichment/over-representation analysis.

    • Ralf Herwig
    • Christopher Hardt
    • Atanas Kamburov
    Protocols
    Nature Protocols
    Volume: 11, P: 1889-1907