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Nature Structural & Molecular Biology (3)
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Showing 1–9 of 9 results

Advanced filters: Author: Ralf Stehle Clear advanced filters

Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex

Crystal structures of a localization element of ASH1 mRNA alone, in complex with its nuclear shuttling protein She2p, and in the cytoplasmic complex with She2p and She3p reveal a step-wise maturation pathway.

Franziska Theresia Edelmann
Andreas Schlundt
Dierk Niessing
Research16 Jan 2017
Nature Structural & Molecular Biology

Volume: 24, P: 152-161
Structural basis for specific RNA recognition by the alternative splicing factor RBM5

The RNA binding protein RBM5 regulates alternative splicing of genes implicated in cancer. Here the authors show structural mechanisms how multiple RNA binding domains of RBM5 cooperate to recognize specific target RNA sequences.

Komal Soni
Pravin Kumar Ankush Jagtap
Michael Sattler
ResearchOpen Access15 Jul 2023
Nature Communications

Volume: 14, P: 1-16
Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation

Roquin controls T-cell activity through interactions with mRNAs of stimulatory receptors. Structural and functional elucidation of its RNA-binding domain reveals how it interacts with constitutive decay elements in the 3' UTR of its targets to regulate their expression.

Andreas Schlundt
Gitta A Heinz
Michael Sattler
Research13 Jul 2014
Nature Structural & Molecular Biology

Volume: 21, P: 671-678
Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68

Sam68 and T-STAR are members of the STAR family of proteins, which regulate various aspects of RNA metabolism. Here, the authors reveal structural features required for alternative splicing regulation by these proteins.

Mikael Feracci
Jaelle N. Foot
Cyril Dominguez
ResearchOpen Access13 Jan 2016
Nature Communications

Volume: 7, P: 1-12
Structure of Rab11–FIP3–Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11

Dual effector binding to the small GTPase Rab11 suggests that membrane-targeting complexes involved in vesicular transport might assemble through multiple weak interactions to create high-avidity assemblies.

Melanie Vetter
Ralf Stehle
Esben Lorentzen
Research10 Aug 2015
Nature Structural & Molecular Biology

Volume: 22, P: 695-702
Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator

Andreas Schlundt
Sophie Buchner
Michael Sattler
ResearchOpen Access21 Apr 2017
Scientific Reports

Volume: 7, P: 1-16
Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

Michelle Vincendeau
Kamyar Hadian
Daniel Krappmann
ResearchOpen Access07 Jan 2016
Scientific Reports

Volume: 6, P: 1-15
Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight

Lore Wagner
Ralf Veit
Stephanie Kullmann
ResearchOpen Access17 Jun 2022
International Journal of Obesity

Volume: 46, P: 1662-1670
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15