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Showing 1–2 of 2 results
Advanced filters: Author: Ralph Hardenberg Clear advanced filters

  • Gómez-Sánchez et al. show that generation of phagophore–endoplasmic reticulum exit sites (ERES) membrane contact sites, mediated by Atg2 and the TRAPPIII complex, triggers Ypt1 activation, which is a signal to initiate phagophore elongation.

    • Rubén Gómez-Sánchez
    • Sabrina Chumpen Ramirez
    • Fulvio Reggiori
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 2319-2334

  • The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated. Here the authors show that phosphorylation by Atg1 inhibits Atg4 at autophagosome formation sites.

    • Jana Sánchez-Wandelmer
    • Franziska Kriegenburg
    • Fulvio Reggiori
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10