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Showing 1–7 of 7 results
Advanced filters: Author: Ralph J. Harte Clear advanced filters

  • Biocatalysis of the chemotherapy drug, doxorubicin, relies on the cytochrome P450 DoxA, which is inefficient. Here, the authors ameliorated the biosynthetic limitations by identifying DoxA redox partners and DnrV, which prevents product inhibition, helping improve microbial production.

    • Arina Koroleva
    • Erika Artukka
    • Mikko Metsä-Ketelä
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-13

  • Recent improvements in the indirect-drive inertial confinement fusion experiments include the achievement of burning plasma state. Here the authors report the scaling of neutron yield in a burning plasma of Deuterium-Tritium fusion reaction by including the mode-2 asymmetry.

    • J. E. Ralph
    • J. S. Ross
    • G. B. Zimmerman
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • A burning plasma, a critical step towards self-sustaining fusion, is achieved at the US National Ignition Facility, with a subset of experiments demonstrating fusion self-heating beyond radiation and conduction losses.

    • A. B. Zylstra
    • O. A. Hurricane
    • G. B. Zimmerman
    ResearchOpen Access
    Nature
    Volume: 601, P: 542-548

  • In this work, Björn Lamprecht et al. found that survival of Hodgkin's lymphoma cells requires activity of the growth factor receptor CSF1R. Transcription of the gene encoding CSF1R was unexpectedly discovered to originate in a specific class of long terminal repeat, a type of repetitive element present in the genome. Transcriptional initiation from this class of long terminal repeats was widely activated in Hodgkin's lymphoma cells, which the authors traced to defects in epigenetic silencing (517–518).

    • Björn Lamprecht
    • Korden Walter
    • Stephan Mathas
    Research
    Nature Medicine
    Volume: 16, P: 571-579

  • In burning plasma, alpha particles from fusion reactions are the dominant source of heating. The design choices that resulted in reaching this state in experiments at the National Ignition Facility are reported.

    • A. L. Kritcher
    • C. V. Young
    • G. B. Zimmerman
    ResearchOpen Access
    Nature Physics
    Volume: 18, P: 251-258