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Showing 1–8 of 8 results
Advanced filters: Author: Ram Savan Clear advanced filters

  • Ram Savan and colleagues report that two miRNAs known to suppress type 3 interferon (IFN) signaling also downregulate type 1IFN signaling in hepatitis C virus (HCV)-infected hepatocytes. The findings provide insights into the mechanisms by which antiviral IFN signaling is inhibited in HCV infection.

    • Abigail Jarret
    • Adelle P McFarland
    • Ram Savan
    Research
    Nature Medicine
    Volume: 22, P: 1475-1481

  • The autoinflammatory pathology associated with alteration of the ZBD domain of the RNA-editing enzyme ADAR1 is driven by signalling that is dependent on the nucleotide sensor ZBP1.

    • Nicholas W. Hubbard
    • Joshua M. Ames
    • Andrew Oberst
    Research
    Nature
    Volume: 607, P: 769-775

  • Innate lymphoid cell–derived cytokine IL-13 promotes the maintenance of intestinal stem cells through stabilization of β-catenin. The circular RNA circPan3 regulates mRNA encoding the cytokine receptor subunit IL-13Rα and downstream IL-13 signaling to stabilize the β-catenin pathway in intestinal stem cells.

    • Frank Soveg
    • Jakob von Moltke
    • Ram Savan
    News & Views
    Nature Immunology
    Volume: 20, P: 114-116

  • Interferon-λ (IFN-λ) curbs neutrophil-mediated intestinal inflammation by diminishing the production of reactive oxygen species and subsequent oxidative stress. This regulatory process is unique to IFN-λ and is independent of interferon-induced transcription and translation programs.

    • Emily A Hemann
    • Johannes Schwerk
    • Ram Savan
    News & Views
    Nature Immunology
    Volume: 18, P: 1061-1062