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Showing 1–7 of 7 results
Advanced filters: Author: Ramon Crehuet Clear advanced filters

  • Polyglutamine (polyQ) tracts are low-complexity regions and their expansion is linked to certain neurodegenerative diseases. Here the authors combine experimental and computational approaches to find that the length of the androgen receptor polyQ tract correlates with its helicity and show that the polyQ helical structure is stabilized by hydrogen bonds between the Gln side chains and main chain carbonyl groups.

    • Albert Escobedo
    • Busra Topal
    • Xavier Salvatella
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Targeting biomedically relevant protein-protein interactions is a long-lasting challenge in medicinal chemistry. Here, the authors develop a single α-helical peptide scaffold that can be tailored to target globular proteins of biomedical interest.

    • Albert Escobedo
    • Jonathan Piccirillo
    • Xavier Salvatella
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Using the site-specific incorporation of isotopically labeled glutamines and NMR, Elena-Real et al. identified helical stability of pathogenic huntingtin exon 1 as a key feature defining the aggregation propensity that triggers Huntington’s disease.

    • Carlos A. Elena-Real
    • Amin Sagar
    • Pau Bernadó
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 309-320

  • DNA sliding clamps are ring-shaped proteins that encircle DNA and harbour polymerases and other factors that promote processive DNA replication. Here the authors use X-ray crystallography, NMR and MD simulations to propose a model for a PCNA sliding mechanism that relies on short-lived polar interactions.

    • Matteo De March
    • Nekane Merino
    • Alfredo De Biasio
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7

  • In this work, Blair and co-authors used cryo-EM and in vitro assays to show that human Ligase 1 (Lig1) and Flap Endonuclease 1 (FEN1) form a toolbelt with the sliding clamp PCNA coordinating the sealing of Okazaki fragments.

    • Kerry Blair
    • Muhammad Tehseen
    • Alfredo De Biasio
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Translesion Synthesis is a process that enables cells to overcome the deleterious effects of replication stalling caused by DNA lesions. Here the authors present a Cryo-EM structure of human Y-family DNA polymerase k (Pol k) bound to PCNA, P/T DNA and an incoming nucleotide; and propose a model for polymerase switching in which “carrier state” Pol k is recruited to PCNA.

    • Claudia Lancey
    • Muhammad Tehseen
    • Alfredo De Biasio
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14