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Showing 1–8 of 8 results
Advanced filters: Author: Ramona Duman Clear advanced filters

  • The number of K+ occupied binding sites in the selectivity filter of potassium ion channels is still under debate. Here, the authors collect diffraction data on the K+ selective NaK channel NaK2K at a wavelength of 3.35 Å, close to the K absorption edge, revealing that all four binding sites in the selectivity filter are fully occupied by K+ ions.

    • Patricia S. Langan
    • Venu Gopal Vandavasi
    • Leighton Coates
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-5

  • Semaphorin 5A (Sema5A) forms complexes with heparan and chondroitin sulfate proteoglycans to regulate neuronal migration. Here, the authors show that the thrombospondin-like repeat 4 (TSR4) of Sema5A enables glycosaminoglycan association, multimerization, and neural progenitor cell distribution.

    • Gergely N. Nagy
    • Xiao-Feng Zhao
    • E. Yvonne Jones
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Twisted gastrulation (TWSG1) controls signaling by Bone Morphogenetic Proteins (BMPs) during embryogenesis and cancer. Here, author report crystal structures of TWSG1 in complex with a BMP ligand and show how TWSG1 inhibits signaling in cells and in vivo.

    • Tomas Malinauskas
    • Gareth Moore
    • Christian Siebold
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Metal ions play essential roles in myriads of biological processes, from catalytic co-factors to supporting protein and nucleic acid structures. Here the authors use long-wavelength X-ray diffraction to locate hundreds of potassium ions taking part in the formation of rRNA tertiary structure, mediating rRNA–protein interactions and supporting ribosomal protein structures and function.

    • Alexey Rozov
    • Iskander Khusainov
    • Gulnara Yusupova
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Cholesterol can function as both a substrate and an inhibitor of the Hedgehog receptor Patched. Structural analysis and molecular dynamics simulations reveal that cholesterol inhibits Patched by inserting into its extracellular domain

    • Amalie F. Rudolf
    • Maia Kinnebrew
    • Christian Siebold
    Research
    Nature Chemical Biology
    Volume: 15, P: 975-982

  • A new sample-delivery method for serial X-ray crystallography exploits the full repetition rate of the X-ray free-electron laser at the LCLS facility, thus enabling efficient, high-speed data collection to solve the three-dimensional structures of viruses.

    • Philip Roedig
    • Helen M Ginn
    • Alke Meents
    Research
    Nature Methods
    Volume: 14, P: 805-810

  • Structural biology has undergone a revolution thanks to cryo-EM and artificial intelligence-based model predictions; nonetheless, experimental phasing continues to be essential. Here, the authors utilize the long-wavelength I23 beamline at Diamond Light Source to solve macromolecular structures using single-wavelength anomalous diffraction techniques, showcasing their proficiency in phasing with lighter atoms.

    • Kamel El Omari
    • Ramona Duman
    • Armin Wagner
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-11