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Showing 1–3 of 3 results
Advanced filters: Author: Ramona M. Absmeier Clear advanced filters

  • AL amyloidosis is caused by the accumulation of overproduced light chain (LC) fragments as fibrils in patient organs and it is the most prevalent systemic amyloidosis. Here, the authors combine biochemical and biophysical experiments to characterise the lag phase of a patient-derived truncated LC and they identify structural transitions that precede fibril formation.

    • Pamina Kazman
    • Ramona M. Absmeier
    • Johannes Buchner
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Biophysical approaches reveal how a mutation in the constant light chain domain of a patient-derived antibody destabilizes the constant domain, prevents the dimerization of the light chain, and makes it more prone to proteolytic cleavage, unleashing the amyloidogenic potential of the isolated variable domain.

    • Georg J. Rottenaicher
    • Ramona M. Absmeier
    • Johannes Buchner
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-11