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Showing 1–6 of 6 results
Advanced filters: Author: Randall C. Starling Clear advanced filters

  • The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphorylates phospholamban to enhance diastolic relaxation in mice.

    • Jenna Scotcher
    • Oleksandra Prysyazhna
    • Philip Eaton
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Heart muscle cells are inactivated when they shorten during ejection, accelerating relaxation to facilitate refilling before the next beat. The authors propose that sequential folding of myosin motors onto the filament backbone may be responsible for shortening-induced de-activation in the heart.

    • Thomas Kampourakis
    • Malcolm Irving
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Contraction of the heart is driven by cyclical interactions between myosin and actin filaments driven by ATP hydrolysis. In this Review, Irving summarizes the basal cardiac cycle of the healthy human heart at the ventricular, cellular, sarcomeric, and molecular levels and the implications for the development of novel therapies for heart disease.

    • Malcolm Irving
    Reviews
    Nature Reviews Cardiology
    Volume: 22, P: 9-19

  • Multicolor imaging employing genetically-encodable fluorescent proteins permits spatiotemporal live cell imaging of multiple cues. Here, authors use multicolor lifetime imaging to visualize quadruple-labelled human immunodeficiency viruses within cellular contexts.

    • Tobias Starling
    • Irene Carlon-Andres
    • Sergi Padilla-Parra
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • In this Review, Tschöpe and colleagues summarize and evaluate the available evidence on the pathogenesis, diagnosis and treatment of myocarditis and inflammatory cardiomyopathy, with special focus on virus-induced and virus-associated myocarditis. The authors also identify knowledge gaps, appraise available experimental models and propose future directions for the field.

    • Carsten Tschöpe
    • Enrico Ammirati
    • Sophie Van Linthout
    Reviews
    Nature Reviews Cardiology
    Volume: 18, P: 169-193