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Neuropsychopharmacology (8)
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Showing 1–21 of 21 results

Advanced filters: Author: Randy D Blakely Clear advanced filters

Cloning and expression of a functional serotonin transporter from rat brain

Randy D. Blakely
Haley E. Berson
Chris C. Bradley
Research07 Nov 1991
Nature

Volume: 354, P: 66-70
Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter

Tadeusz Pacholczyk
Randy D. Blakely
Susan G. Amara
Research28 Mar 1991
Nature

Volume: 350, P: 350-354
Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors

The serotonin transporter, targeted by several medications, terminates neurotransmission by clearing serotonin from the synaptic cleft. Combining biochemical results with in silico data, the authors show the key interactions that initiate substrate transport.

Ralph Gradisch
Katharina Schlögl
Thomas Stockner
ResearchOpen Access10 Jan 2024
Nature Communications

Volume: 15, P: 1-15
Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner

Hematopoietic stem cells (HSCs) replenish blood cells. Here, Luis et al., identify a feedback mechanism by which IL-1 secreted by activated platelets signals through niche Lepr+ cells to activate HSCs and restore platelet homeostasis.

Tiago C. Luis
Nikolaos Barkas
Sten Eirik W. Jacobsen
ResearchOpen Access28 Sept 2023
Nature Communications

Volume: 14, P: 1-18
SNARE-ing neurotransmitter transporters

A new study demonstrates a link between neurotransmitter secretion and reuptake by showing that syntaxin 1A also interacts with—and regulates—GAT1 GABA transporters.

Randy D. Blakely
Uhna Sung
News & Views01 Oct 2000
Nature Neuroscience

Volume: 3, P: 969-971
Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits

Kelly et al. describe two cerebellum–thalamus–mPFC pathways in mice that regulate social and repetitive behavior. PC activation in Rcrus1 and posterior vermis improved social and reduced repetitive behaviors, respectively, in PC-Tsc1 mutant mice.

Elyza Kelly
Fantao Meng
Peter T. Tsai
Research13 Jul 2020
Nature Neuroscience

Volume: 23, P: 1102-1110
The Proinflammatory Cytokines Interleukin-1beta and Tumor Necrosis Factor-Alpha Activate Serotonin Transporters

Chong-Bin Zhu
Randy D Blakely
William A Hewlett
Research01 Feb 2006
Neuropsychopharmacology

Volume: 31, P: 2121-2131
Interleukin-1 Receptor Activation by Systemic Lipopolysaccharide Induces Behavioral Despair Linked to MAPK Regulation of CNS Serotonin Transporters

Chong-Bin Zhu
Kathryn M Lindler
William A Hewlett
Research08 Sept 2010
Neuropsychopharmacology

Volume: 35, P: 2510-2520
Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse

Alex G Nackenoff
Alexandra B Moussa-Tooks
Randy D Blakely
Research30 Oct 2015
Neuropsychopharmacology

Volume: 41, P: 1733-1741
Networking in Autism: Leveraging Genetic, Biomarker and Model System Findings in the Search for New Treatments

Jeremy Veenstra-VanderWeele
Randy D Blakely
Reviews21 Sept 2011
Neuropsychopharmacology

Volume: 37, P: 196-212
Kappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant

Felix P. Mayer
Adele Stewart
Sammanda Ramamoorthy
ResearchOpen Access29 May 2025
Molecular Psychiatry

Volume: 30, P: 4651-4664
A transient placental source of serotonin for the fetal forebrain

Alexandre Bonnin
Nick Goeden
Pat Levitt
Research20 Apr 2011
Nature

Volume: 472, P: 347-350
Behaviorally penetrant, anomalous dopamine efflux exposes sex and circuit dependent regulation of dopamine transporters

Adele Stewart
Felix P. Mayer
Randy D. Blakely
Research18 Sept 2022
Molecular Psychiatry

Volume: 27, P: 4869-4880
A requirement of serotonergic p38α mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors

N L Baganz
K M Lindler
R D Blakely
ResearchOpen Access03 Nov 2015
Translational Psychiatry

Volume: 5, P: e671
Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment

Christopher L Muller
Allison MJ Anacker
Jeremy Veenstra-VanderWeele
Research23 Aug 2016
Neuropsychopharmacology

Volume: 42, P: 427-436
The SSRI Citalopram Affects Fetal Thalamic Axon Responsiveness to Netrin-1 In vitro Independently of SERT Antagonism

Alexandre Bonnin
Le Zhang
Pat Levitt
Research14 Mar 2012
Neuropsychopharmacology

Volume: 37, P: 1879-1884
Serotonin-releasing agents with reduced off-target effects

Felix P. Mayer
Marco Niello
Harald H. Sitte
ResearchOpen Access09 Nov 2022
Molecular Psychiatry

Volume: 28, P: 722-732
Serotonin transporter inhibition and 5-HT_2C receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice

Adele Stewart
Gwynne L. Davis
Randy D. Blakely
ResearchOpen Access21 Dec 2018
Neuropsychopharmacology

Volume: 44, P: 994-1006
Modified structure of the human serotonin transporter promoter

N L Flattem
R D Blakely
Research28 Jan 2000
Molecular Psychiatry

Volume: 5, P: 110-115
Dynamin, a membrane-remodelling GTPase

The dynamin GTPase mediates membrane remodelling during endocytosis. Through complementary approaches, including structural and genetic studies, the mechanisms by which dynamin regulates membrane fission events, and the unique physiological roles of its three isoforms, are becoming clear.

Shawn M. Ferguson
Pietro De Camilli
Reviews11 Jan 2012
Nature Reviews Molecular Cell Biology

Volume: 13, P: 75-88
Norepinephrine Modulates Glutamatergic Transmission in the Bed Nucleus of the Stria Terminalis

Regula E Egli
Thomas L Kash
Danny G Winder
Research15 Dec 2004
Neuropsychopharmacology

Volume: 30, P: 657-668