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Showing 1–2 of 2 results
Advanced filters: Author: Ranjit Sivanandham Clear advanced filters

  • HIV infection results in the depletion of CD4+ T cells overtime and the loss of coordinated cellular immunity, but how this corresponds to the SIV infected African Green Monkey (AGM) model of non-progressive disease is not known. Here the authors assess the impact of experimental CD4+ T cell depletion in AGM and show that lack of disease progression and resistance to AIDS in this model are independent of CD4+ T cell loss.

    • Quentin Le Hingrat
    • Paola Sette
    • Ivona Pandrea
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Control of HIV and SIV infection is largely thought to be achieved through direct lysis of target cells. Here, using mathematical modelling of viral load data from rhesus macaques, the authors propose that virus control is best explained by the combination of cytolytic and non-cytolytic effects.

    • Benjamin B. Policicchio
    • Erwing Fabian Cardozo-Ojeda
    • Ruy M. Ribeiro
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13