The brain is a highly active organ that relies almost exclusively on glucose as its energy source, but whether glucose is directly taken up by neurons or whether it is converted to lactate by astrocytes before neuronal uptake is still unclear. Here the authors perform in vivoimaging in awake mice and show evidence in support of the direct uptake of glucose by neurons.
- Iben Lundgaard
- Baoman Li
- Maiken Nedergaard
