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Showing 1–6 of 6 results
Advanced filters: Author: Rashmi Chugh Clear advanced filters

  • Tumours with alterations in SWI/SNF complex have elevated EZH2 activity, which is associated with poor prognosis and tumour progression. Here, the authors report a phase 2 basket study investigating the safety and efficacy of oral tazemetostat (EZH2 inhibitor) in patients with solid tumours harbouring SWI/SNF driver mutations.

    • Mrinal Gounder
    • Patrick Schöffski
    • Nizar M. Tannir
    ResearchOpen Access
    Nature Communications
    P: 1-12

  • Comprehensive molecular profiles are required to understand and treat sarcomas, which comprise more than 70 different subtypes. Here, the authors profile the genomic landscape of 7494 sarcomas across 44 histologies using targeted panel sequencing and identify potential therapeutic targets.

    • Mrinal M. Gounder
    • Narasimhan P. Agaram
    • Dexter X. Jin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Clinical exome and transcriptome sequencing of 500 adult patients with metastatic solid tumours of diverse lineage and biopsy site, as part of the Michigan Oncology Sequencing (MI-ONCOSEQ) Program.

    • Dan R. Robinson
    • Yi-Mi Wu
    • Arul M. Chinnaiyan
    Research
    Nature
    Volume: 548, P: 297-303

  • Arul Chinnaiyan and colleagues report the results of prospective clinical sequencing of 11 estrogen receptor–positive metastatic breast cancers. They identify ESR1 mutations affecting the ligand-binding domain in six hormone-resistant metastatic breast cancers and show that the mutant estrogen receptors are constitutively active and continue to be responsive to anti-estrogen therapies in vitro.

    • Dan R Robinson
    • Yi-Mi Wu
    • Arul M Chinnaiyan
    Research
    Nature Genetics
    Volume: 45, P: 1446-1451