Gut microbiota contribute to the pathogenesis of ulcerative colitis (UC), but the molecular mechanisms are still unclear. Here the authors show that colonic fluid from patients with UC is enriched for bacteria extracellular vesicles (BEV) coated with host IgA, and that these IgA-coated BEV may activate CD89+ immune cells to aggravate inflammation and colitis in mouse models.
- Himadri B. Thapa
- Christina A. Passegger
- Stefan Schild
