Nature Search

Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells

Kazumi Ebine
Krishan Kumar
Hidayatullah G. Munshi
ResearchOpen Access05 Sept 2018
Scientific Reports

Volume: 8, P: 1-11
Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a β1-integrin-FAK-YAP1/TAZ signaling pathway

Xiaoyu Xiang
Yuanguo Wang
Ningling Kang
ResearchOpen Access23 Jan 2018
npj Precision Oncology

Volume: 2, P: 1-10
The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis

Cancer-associated fibroblasts (CAFs) are the main component of the stroma in pancreatic cancer, but their tissue of origin remains to be defined. Here the authors perform lineage tracing and single cell RNA sequencing in mice and suggest the splanchnic mesenchyme as the tissue of origin for CAFs.

Lu Han
Yongxia Wu
Gustavo Leone
ResearchOpen Access03 Jan 2023
Nature Communications

Volume: 14, P: 1-12
Evidence for the existence of an HP1-mediated subcode within the histone code

Gwen Lomberk
Debora Bensi
Raul Urrutia
Research12 Mar 2006
Nature Cell Biology

Volume: 8, P: 407-415
Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Pancreatic ductal adenocarcinoma (PDAC) is a complex disease and its underlying epigenomic heterogeneity is not fully understood. Here, the authors utilize patient-derived PDAC xenografts to define the epigenomic landscape of PDAC, highlighting chromatin states linked to differing disease aggressiveness and survival.

Gwen Lomberk
Yuna Blum
Raul Urrutia
ResearchOpen Access17 May 2018
Nature Communications

Volume: 9, P: 1-10
Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation

Daniel Grasso
Jennifer Bintz
Juan L. Iovanna
ResearchOpen Access30 Nov 2015
Scientific Reports

Volume: 5, P: 1-11
Identification of novel loci for multiple myeloma when comparing with its precursor condition monoclonal gammopathy of unknown significance

Christopher Staffi Buradagunta
Shahram Arsang-Jang
Jing Dong
Research02 Nov 2023
Leukemia

Volume: 38, P: 383-385
Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine

In pancreatic cancer, the epigenomic landscape can strongly impact the disease phenotype. Here, the authors discuss recent advances in our understanding of pancreatic cancer epigenomics, and how this knowledge can integrate with precision medicine approaches in this lethal disease.

Gwen Lomberk
Nelson Dusetti
Raul Urrutia
ReviewsOpen Access28 Aug 2019
Nature Communications

Volume: 10, P: 1-10
Erratum: Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes

Thiago M De Assuncao
Yan Sun
Robert C Huebert
Amendments and Corrections28 Sept 2015
Laboratory Investigation

Volume: 95, P: 1218
Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing

Jian-rong Li
Shahram Arsang-Jang
Chao Cheng
ResearchOpen Access06 Mar 2024
Blood Cancer Journal

Volume: 14, P: 1-9
KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress

Yizeng Yang
Dharmendra Bhargava
Jonathan P. Katz
ResearchOpen Access02 May 2023
Cell Death & Disease

Volume: 14, P: 1-10
NUPR1 protects against hyperPARylation-dependent cell death

NUPR1 binds to PARP1 and inhibits PARP1 activity in pancreatic cancer cells, with the NUPR1 inhibitor ZZW-115 abolishing the protective effect of NUPR1, inducing strong hyperPARylation and cell death by mitochondrial dysfunction.

Patricia Santofimia-Castaño
Can Huang
Juan Iovanna
ResearchOpen Access22 Jul 2022
Communications Biology

Volume: 5, P: 1-12
Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction

Nicolas A. Fraunhoffer
Analía Meilerman Abuelafia
Juan Iovanna
ResearchOpen Access17 Aug 2022
npj Precision Oncology

Volume: 6, P: 1-16
Impact of integrated translational research on clinical exome sequencing

Eric W. Klee
Margot A. Cousin
Konstantinos N. Lazaridis
Research04 Nov 2020
Genetics in Medicine

Volume: 23, P: 498-507
Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway

Seungmae Seo
Angela Mathison
Raul Urrutia
ResearchOpen Access10 Oct 2018
Scientific Reports

Volume: 8, P: 1-13
Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

Patricia Santofimia-Castaño
Wenjun Lan
Juan Iovanna
ResearchOpen Access19 Nov 2018
Scientific Reports

Volume: 8, P: 1-16
Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras^G12D-induced senescence

D Grasso
M N Garcia
J L Iovanna
ResearchOpen Access06 Jun 2014
Cell Death & Differentiation

Volume: 21, P: 1633-1641
Evidence Revealing Deregulation of The KLF11-Mao A Pathway in Association with Chronic Stress and Depressive Disorders

Sharonda Harris
Shakevia Johnson
Jun Ming Wang
Research15 Dec 2014
Neuropsychopharmacology

Volume: 40, P: 1373-1382
Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis

Robert C Huebert
Kumaravelu Jagavelu
Vijay H Shah
Research19 Jul 2010
Laboratory Investigation

Volume: 90, P: 1770-1781
Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes

Thiago M De Assuncao
Yan Sun
Robert C Huebert
Research13 Apr 2015
Laboratory Investigation

Volume: 95, P: 684-696

Search

Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells

Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a β1-integrin-FAK-YAP1/TAZ signaling pathway

The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis

Evidence for the existence of an HP1-mediated subcode within the histone code

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation

Identification of novel loci for multiple myeloma when comparing with its precursor condition monoclonal gammopathy of unknown significance

Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine

Erratum: Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes

Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing

KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress

NUPR1 protects against hyperPARylation-dependent cell death

Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction

Impact of integrated translational research on clinical exome sequencing

Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras^G12D-induced senescence

Evidence Revealing Deregulation of The KLF11-Mao A Pathway in Association with Chronic Stress and Depressive Disorders

Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis

Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes

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