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Showing 1–9 of 9 results
Advanced filters: Author: Ravi L. Rungta Clear advanced filters

  • Combination of optogenetics and BOLD fMRI is routinely used to map neuronal activity upon photostimulation. Here the authors show that light, shone at intensities used in optogenetic studies, dilates vessels and increases blood flow independently of exogenous light-sensitive proteins in the mouse brain.

    • Ravi L Rungta
    • Bruno-Félix Osmanski
    • Serge Charpak
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Neurovascular coupling refers to changes in cerebral blood flow in response to neuronal stimulation, but to what extent this change can report neuronal activation is not known. Here the authors develop transfer functions between neural calcium signals and functional ultrasound changes in blood volume in co-registered single voxel brain volumes.

    • Ali-Kemal Aydin
    • William D. Haselden
    • Davide Boido
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Rungta et al. utilized single whisker stimulation to map out functional hyperemia along vascular arbours from layer II/III to the surface of primary somatosensory cortex, in anesthetized and awake Thy1-GCaMP6 mice. They demonstrated the presence of a functional diversity not only between different brain regions but also at the level of different vascular arbours within supragranular layers of the cerebral cortex.

    • Ravi L. Rungta
    • Marc Zuend
    • Serge Charpak
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11

  • The spatial relationship between neuronal and vascular activity remains highly debated. In this study, the authors used multiscale optical imaging to show how vascular architecture limits the spatial specificity of neurovascular coupling.

    • Éric Martineau
    • Antoine Malescot
    • Ravi L. Rungta
    Research
    Nature Neuroscience
    Volume: 27, P: 2101-2114

  • Neuronal activity leads to a local increase in blood flow and volume, a process termed hyperaemia. Here, the authors employ multiple imaging approaches of neuronal and vascular activity at varying resolution to delineate the spatiotemporal dynamics of neurovascular coupling evoked by odours in the olfactory bulb.

    • Davide Boido
    • Ravi L. Rungta
    • Serge Charpak
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • During synaptic activation, the function of astrocyte endfeet depends on the vascular target: at the capillary, but not at the arteriole, a newly described P2X1R–phospholipase D2 pathway modulates prostaglandin E2 release and vessel dilation.

    • Ravi L Rungta
    • Serge Charpak
    News & Views
    Nature Neuroscience
    Volume: 19, P: 1539-1541

  • Calcium signalling in glial cells couples neuronal activity to regional changes in cerebral blood flow, but the polarity of its effect on the diameter of neighbouring arterioles has remained controversial. This paper reveals that when the glycolytic state of the brain is enhanced by lower tissue oxygenation, glia-mediated vasoconstrictions convert to vasodilations.

    • Grant R. J. Gordon
    • Hyun B. Choi
    • Brian A. MacVicar
    Research
    Nature
    Volume: 456, P: 745-749

  • In this Review, Wardlaw et al. discuss the anatomy, physiology and pathology of perivascular spaces, particularly as seen with MRI in humans, and consider translation from models to humans to highlight knowns, unknowns, controversies and clinical relevance.

    • Joanna M. Wardlaw
    • Helene Benveniste
    • Sandra E. Black
    Reviews
    Nature Reviews Neurology
    Volume: 16, P: 137-153