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Showing 1–2 of 2 results
Advanced filters: Author: Raychel M. Lewis Clear advanced filters

  • A trans-ancestry genome-wide association study of serum urate levels identifies 183 loci influencing this trait. Enrichment analyses, fine-mapping and colocalization with gene expression in 47 tissues implicate the kidney and liver as key target organs and prioritize potential causal genes.

    • Adrienne Tin
    • Jonathan Marten
    • Anna Köttgen
    Research
    Nature Genetics
    Volume: 51, P: 1459-1474

  • The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant role for ABCG2 in urate excretion in both the kidney and intestine.

    • Kazi Mirajul Hoque
    • Eryn E. Dixon
    • Owen M. Woodward
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15