Nature Search

Adjuvant chemotherapy for colon carcinoma with positive lymph nodes: use and benefit in routine health care practice

C Bouchardy
P-E Queneau
A P Sappino
ResearchOpen Access30 Oct 2001
British Journal of Cancer

Volume: 85, P: 1251-1257
Prognostic factors and survival disparities in right-sided versus left-sided colon cancer

Mohammad Asghari-Jafarabadi
Simon Wilkins
Paul John McMurrick
ResearchOpen Access29 May 2024
Scientific Reports

Volume: 14, P: 1-13
Intestinal Maturation in the Rat: the Effect of Glucocorticoids on Sodium, Potassium, Water and Glucose Absorption

Raymond Meneely
Fayez K Ghishan
Research01 Sept 1982
Pediatric Research

Volume: 16, P: 776-778
Intestinal Maturation: In Vivo Magnesium Transport

Raymond Meneely
Laura Leeper
Fayez K Ghishan
Research01 Apr 1982
Pediatric Research

Volume: 16, P: 295-298
Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells

K A Benhadji
M Serova
E Raymond
ResearchOpen Access25 Nov 2008
British Journal of Cancer

Volume: 99, P: 1808-1815
Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor

Zhonghua Zhang
Raymond N DuBois
Research06 Aug 2001
Oncogene

Volume: 20, P: 4450-4456
Critical role of interferons in gastrointestinal injury repair

Despite being prevalent yet well studied, ulcerative colitis still has poorly characterized pathophysiology. Here the authors use mouse colitis models to find that type I and III interferon (IFN) both contribute to ameliorating the disease, with IFN signaling in either the epithelial or hematopoietic compartment sufficient for this protective effect.

Constance McElrath
Vanessa Espinosa
Sergei V. Kotenko
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-15
Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants

Here, the authors show that giving probiotics to very low birth weight preterm babies can help reduce harmful antibiotic-resistant bacteria in the gut and support the development of a healthier microbiome.

Raymond Kiu
Elizabeth M. Darby
Lindsay J. Hall
ResearchOpen Access14 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

The cytokine oncostatin M drives intestinal inflammation in mice, and its abundance in the intestine of patients with inflammatory bowel disease predicts response to tumor necrosis factor–neutralizing therapy.

Nathaniel R West
Ahmed N Hegazy
Fiona Powrie
Research03 Apr 2017
Nature Medicine

Volume: 23, P: 579-589
CD45 regulates GM-CSF, retinoic acid and T-cell homing in intestinal inflammation

A Samarakoon
Y A Shim
P Johnson
Research23 Mar 2016
Mucosal Immunology

Volume: 9, P: 1514-1527
Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

Jan Wijnholds
Raymond Evers
Piet Borst
Research01 Nov 1997
Nature Medicine

Volume: 3, P: 1275-1279
Eicosanoids and cancer

Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that have been implicated in inflammation and cancer. This Review highlights the roles of eicosanoids in tumours and their microenvironment, and how their signalling pathways might be exploited to develop more effective cancer chemopreventive and/or therapeutic agents.

Dingzhi Wang
Raymond N. DuBois
Reviews19 Feb 2010
Nature Reviews Cancer

Volume: 10, P: 181-193
Bidirectional Transport of Radioactively Labelled Axoplasmic Components

RAYMOND J. LASEK
Research01 Dec 1967
Nature

Volume: 216, P: 1212-1214
Particular genomic and virulence traits associated with preterm infant-derived toxigenic Clostridium perfringens strains

Genomic and phenotypic analyses of 272 infant-associated Clostridium perfringens isolates suggest that pfoA is an important toxin gene in C. perfringens linked with preterm infant intestinal diseases.

Raymond Kiu
Alexander G. Shaw
Lindsay J. Hall
ResearchOpen Access25 May 2023
Nature Microbiology

Volume: 8, P: 1160-1175
The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer

Giulia Trimaglio
Tamara Sneperger
Yoann Rombouts
ResearchOpen Access26 Mar 2024
Scientific Reports

Volume: 14, P: 1-14
Influence of stage at diagnosis on survival differences for rectal cancer in three European populations

E Monnet
J Faivre
I Garau
ResearchOpen Access10 Sept 1999
British Journal of Cancer

Volume: 81, P: 463-468
Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts

Heterologous expression of engineered gas vesicles allows noninvasive, deep-tissue ultrasound visualization of engineered bacteria in vivo in mouse tumour models and in the gastrointestinal tract.

Raymond W. Bourdeau
Audrey Lee-Gosselin
Mikhail G. Shapiro
Research04 Jan 2018
Nature

Volume: 553, P: 86-90
Activation of nuclear hormone receptor peroxisome proliferator–activated receptor-δ accelerates intestinal adenoma growth

Rajnish A Gupta
Dingzhi Wang
Raymond N DuBois
Research01 Feb 2004
Nature Medicine

Volume: 10, P: 245-247
JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans

Anne M. Fourie
Xiaoli Cheng
Nishit B. Modi
ResearchOpen Access30 Jul 2024
Scientific Reports

Volume: 14, P: 1-12
Gata6⁺ resident peritoneal macrophages promote the growth of liver metastasis

GLPMs represent a population of fetal liver derived large peritoneal cavity Gata6+ macrophages, with the capacity to invade the tissues they surround. Here, in experimental colon cancer liver metastasis models, the authors show that GLPMs invade liver metastasis directly from the peritoneum, promoting liver metastases growth.

Mokarram Hossain
Raymond Shim
Paul Kubes
ResearchOpen Access29 Jul 2022
Nature Communications

Volume: 13, P: 1-13
The survival of B cells is compromised in kidney disease

Kidney disease compromises the humoral immune response to vaccines and infections. Here authors show in multiple murine kidney disease models that apoptosis of germinal center B cells via hippuric-acid-driven loss of mitochondrial membrane potential is a central cause of diminished antibody response.

Doureradjou Peroumal
Chetan V. Jawale
Partha S. Biswas
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-19
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity

Local delivery of mRNA-based immunotherapy represents an option for cancer therapy. Here the authors report that intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity in preclinical cancer models.

Ahmed E. I. Hamouda
Jessica Filtjens
Damya Laoui
ResearchOpen Access06 Dec 2024
Nature Communications

Volume: 15, P: 1-20
Na⁺ −K⁺ −Cl⁻ co-transport in the intestine of a marine teleost

Mark W. Musch
Stephanie A. Orellana
Raymond A. Frizzell
Research25 Nov 1982
Nature

Volume: 300, P: 351-353
A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients

Longitudinal changes in gene expression, splicing patterns and adaptive immune repertoire in murine models of colitis are examined and associated with histologic inflammation in mice and in patients with inflammatory bowel disease.

Lauren A. Peters
Joshua R. Friedman
Bojan Losic
ResearchOpen Access24 Jan 2023
Communications Biology

Volume: 6, P: 1-12
Expression of TRAIL and TRAIL receptors in normal and malignant tissues

Raymond A DANIELS
Helen TURLEY
Gavin R SCREATON
Research01 Jun 2005
Cell Research

Volume: 15, P: 430-438
Current development of mTOR inhibitors as anticancer agents

Following the development of the first mTOR inhibitor that successfully improves therapeutic survival in cancer, Raymond and colleagues look at how novel biomarker identification and the use of multitargeted and multimodality therapies could advance the next generation of these drugs.

Sandrine Faivre
Guido Kroemer
Eric Raymond
Reviews01 Aug 2006
Nature Reviews Drug Discovery

Volume: 5, P: 671-688
Phospholipid scramblases TMEM16F and Xkr8 mediate distinct features of phosphatidylserine (PS) externalization and immune suppression to promote tumor growth

Varsha Gadiyar
Rachael Pulica
Raymond B. Birge
ResearchOpen Access06 Nov 2025
Cell Death Discovery

Volume: 11, P: 1-13
Detection of circulating carcinoma cells by telomerase activity

L R Gauthier
C Granotier
F D Boussin
ResearchOpen Access27 Feb 2001
British Journal of Cancer

Volume: 84, P: 631-635
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

Disulfiram is metabolized into copper–diethyldithiocarbamate, which binds to NPL4 and induces its aggregation in cells, leading to blockade of the p97–NPL4–UFD1 pathway and induction of a complex cellular phenotype that results in cell death.

Zdenek Skrott
Martin Mistrik
Jiri Bartek
Research06 Dec 2017
Nature

Volume: 552, P: 194-199
MicroRNA expression profiles classify human cancers

Jun Lu
Gad Getz
Todd R. Golub
Research09 Jun 2005
Nature

Volume: 435, P: 834-838
The gut microbiome-prostate cancer crosstalk is modulated by dietary polyunsaturated long-chain fatty acids

Here, using murine models of prostate cancer, the authors show that reduced fecal microbiota alpha-diversity correlates with increased prostate tumor burden, and that Omega-3 prebiotic supplementation reduces prostate cancer up-grading associated with a reduction of gut Ruminococcaceae and fecal butyrate levels.

Gabriel Lachance
Karine Robitaille
Vincent Fradet
ResearchOpen Access23 Apr 2024
Nature Communications

Volume: 15, P: 1-15
The solution structure of an HMG-I(Y)–DNA complex defines a new architectural minor groove binding motif

Jeffrey R. Huth
Carole A. Bewley
G. Marius Clore
Research01 Aug 1997
Nature Structural Biology

Volume: 4, P: 657-665
Sequence of the human insulin gene

Graeme I. Bell
Raymond L. Pictet
Howard M. Goodman
Research06 Mar 1980
Nature

Volume: 284, P: 26-32
Retrospective detection of monkeypox virus in the testes of nonhuman primate survivors

Detection of monkeypox viruses (MPXV) in archival testes samples from acute and convalescent MPXV-infected macaques provides evidence supporting the potential for sexual transmision of MPXV.

Jun Liu
Eric M. Mucker
Xiankun Zeng
Research17 Oct 2022
Nature Microbiology

Volume: 7, P: 1980-1986
The role of autophagy in cancer development and response to therapy

Yasuko Kondo
Takao Kanzawa
Seiji Kondo
Reviews01 Sept 2005
Nature Reviews Cancer

Volume: 5, P: 726-734
Adaptive peptide dispersions enable drying-induced biomolecule encapsulation

Here the authors design tripeptides that form dynamic soluble dispersions and undergo phase separation upon drying to assemble into porous particles. This evaporation-driven emulsification can be harnessed to encapsulate and stabilize biomolecules.

Dhwanit R. Dave
Salma Kassem
Rein V. Ulijn
ResearchOpen Access05 Aug 2025
Nature Materials

Volume: 24, P: 1465-1475
Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer

Bo Cen
Jie Wei
Raymond N. DuBois
Research12 Aug 2021
Oncogene

Volume: 40, P: 5984-5992
Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation

Here, the authors show that deletion of Pglyrp1 promotes antitumor immunity owing to its inhibitory function in CD8⁺ T cells and that targeting it can inhibit development of autoimmune neuroinflammation. These findings indicate that PGLYRP1 might be a target for immunotherapy.

Alexandra Schnell
Linglin Huang
Vijay K. Kuchroo
Research12 Oct 2023
Nature Immunology

Volume: 24, P: 1908-1920
A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer

Schmidt et al. show that the translation initiation factor eIF2B5 regulates stress responses and MYC translation to prevent apoptosis, thereby presenting a targetable vulnerability in colorectal cancer.

Stefanie Schmidt
David Gay
Armin Wiegering
Research04 Nov 2019
Nature Cell Biology

Volume: 21, P: 1413-1424
Antiproliferative effects of sapacitabine (CYC682), a novel 2′-deoxycytidine-derivative, in human cancer cells

M Serova
C M Galmarini
E Raymond
ResearchOpen Access17 Jul 2007
British Journal of Cancer

Volume: 97, P: 628-636
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

There are distinct hypermethylation patterns in gene promoters in hepatocellular carcinomas (HCCs). Here, the authors show that the enhancer of C/EBPβ is recurrently hypomethylated in human HCCs, recapitulating this in a transgenic murine model and linking aberrant enhancer hypomethylation to hepatocarcinogenesis.

Lei Xiong
Feng Wu
Ka-Fai To
ResearchOpen Access18 Jan 2019
Nature Communications

Volume: 10, P: 1-14
Glasses come to order

Raymond Jeanloz
Quentin Williams
News & Views25 Apr 1991
Nature

Volume: 350, P: 659-660
Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

Rajnish A. Gupta
Raymond N. DuBois
Reviews01 Oct 2001
Nature Reviews Cancer

Volume: 1, P: 11-21
AI powered quantification of nuclear morphology in cancers enables prediction of genome instability and prognosis

John Abel
Suyog Jain
Amaro Taylor-Weiner
ResearchOpen Access19 Jun 2024
npj Precision Oncology

Volume: 8, P: 1-14
WRN helicase is a synthetic lethal target in microsatellite unstable cancers

Depletion of the DNA helicase WRN induced double-stranded DNA breaks, and promoted apoptosis and cell cycle arrest selectively in cancers with microsatellite instability, indicating that WRN is a promising drug target for the treatment of these cancers.

Edmond M. Chan
Tsukasa Shibue
Adam J. Bass
Research10 Apr 2019
Nature

Volume: 568, P: 551-556
Distinct genetic liability profiles define clinically relevant patient strata across common diseases

Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

Lucia Trastulla
Georgii Dolgalev
Michael J. Ziller
ResearchOpen Access01 Jul 2024
Nature Communications

Volume: 15, P: 1-28
IL-4 inhibits TGF-β-induced Foxp3⁺ T cells and, together with TGF-β, generates IL-9⁺ IL-10⁺ Foxp3⁻ effector T cells

Foxp3 is required for the generation and function of regulatory T cells. Kuchroo and colleagues find that interleukin 4 blocks the generation of these cells but promotes T helper cells that produce interleukins 9 and 10.

Valérie Dardalhon
Amit Awasthi
Vijay K Kuchroo
Research09 Nov 2008
Nature Immunology

Volume: 9, P: 1347-1355
ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system

ARIH2 is a RING-between-RING E3 ligase. Pellegrini and colleagues show that ARIH2 is needed to limit excessive NF-κB signaling in DCs. Loss of ARIH2 is associated with embryonic death due to excessive inflammatory responses.

Amy E Lin
Gregor Ebert
Marc Pellegrini
Research25 Nov 2012
Nature Immunology

Volume: 14, P: 27-33
Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

Henning Walczak
Robert E. Miller
David H. Lynch
Research01 Feb 1999
Nature Medicine

Volume: 5, P: 157-163

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