Nature Search

The structure of I-Crel, a Group I intron-encoded homing endonuclease

Patrick J. Heath
Kathryn M. Stephens
Barry L. Stoddard
Research01 Jun 1997
Nature Structural Biology

Volume: 4, P: 468-476
Werner syndrome through the lens of tissue and tumour genomics

Mari Tokita
Scott R. Kennedy
Raymond J. Monnat
ResearchOpen Access25 Aug 2016
Scientific Reports

Volume: 6, P: 1-10
Cellular heterogeneity and therapeutic response profiling of human IDH + glioma stem cell cultures

Nyasha Chambwe
Scott R. Kennedy
Raymond J. Monnat Jr.
ResearchOpen Access21 Dec 2025
Scientific Reports

Volume: 16, P: 1-16
Computational redesign of endonuclease DNA binding and cleavage specificity

Redesign of the I-MsoI endonuclease binds and cleaves the new recognition site ∼10,000-fold more effectively than does the wild-type enzyme, with a level of target discrimination comparable to the original endonuclease.

Justin Ashworth
James J. Havranek
David Baker
Research01 Jun 2006
Nature

Volume: 441, P: 656-659
DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI

Karen E. Flick
Melissa S. Jurica
Barry L. Stoddard
Research01 Jul 1998
Nature

Volume: 394, P: 96-101
The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites

Brett S. Chevalier
Raymond J. Monnat Jr.
Barry L. Stoddard
Research01 Apr 2001
Nature Structural Biology

Volume: 8, P: 312-316
A novel endonuclease mechanism directly visualized for I-PpoI

Eric A. Galburt
Brett Chevalier
Barry L. Stoddard
Research01 Dec 1999
Nature Structural Biology

Volume: 6, P: 1096-1099
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

Elijahu Berkovich
Raymond J. Monnat Jr.
Michael B. Kastan
Research07 May 2007
Nature Cell Biology

Volume: 9, P: 683-690
WRN helicase is a synthetic lethal target in microsatellite unstable cancers

Depletion of the DNA helicase WRN induced double-stranded DNA breaks, and promoted apoptosis and cell cycle arrest selectively in cancers with microsatellite instability, indicating that WRN is a promising drug target for the treatment of these cancers.

Edmond M. Chan
Tsukasa Shibue
Adam J. Bass
Research10 Apr 2019
Nature

Volume: 568, P: 551-556
DNA polymerases and human disease

There are now 14 DNA polymerases in the human genome. This article explores the function of these molecules in replicating DNA, their regulation and involvement in disease, and how specific properties of each polymerase might be targeted for therapeutic ends.

Lawrence A. Loeb
Raymond J. Monnat Jr
Reviews01 Aug 2008
Nature Reviews Genetics

Volume: 9, P: 594-604
Werner and Hutchinson–Gilford progeria syndromes: mechanistic basis of human progeroid diseases

Recent data on the genetic and molecular basis of progeroid syndromes have shed light onto the nuclear metabolic defects that might accelerate ageing. What are the mechanistic features of progeroid syndromes? And how can these findings help us understand normal ageing?

Brian A. Kudlow
Brian K. Kennedy
Raymond J. Monnat Jr
Reviews01 May 2007
Nature Reviews Molecular Cell Biology

Volume: 8, P: 394-404
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

The cytotoxic effects of topoisomerase I inhibitors such as camptothecin can be modulated by replication fork reversal, in a process that requires Poly(ADP-ribose) polymerase (PARP) activity. Here human RECQ1 helicase is shown to restore such regressed replication forks, whereas PARP1 activity restrains this RECQ1 function.

Matteo Berti
Arnab Ray Chaudhuri
Alessandro Vindigni
Research10 Feb 2013
Nature Structural & Molecular Biology

Volume: 20, P: 347-354
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

Nikolai Windbichler
Miriam Menichelli
Andrea Crisanti
Research20 Apr 2011
Nature

Volume: 473, P: 212-215
Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites

Elijahu Berkovich
Raymond J Monnat Jr
Michael B Kastan
Protocols01 May 2008
Nature Protocols

Volume: 3, P: 915-922
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
Tumour predisposition and cancer syndromes as models to study gene–environment interactions

This Perspective advocates the study of tumour predisposition syndromes as an opportunity to better identify gene–environment interactions that influence cancer risk. Understanding syndrome-associated molecular mechanisms may provide new and more effective ways to prevent exposure-associated cancers in the general population.

Michele Carbone
Sarah T. Arron
Haining Yang
Reviews29 May 2020
Nature Reviews Cancer

Volume: 20, P: 533-549
Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype

Ashwini S. Kamath-Loeb
Diego G. Zavala-van Rankin
Gabriela E. Mercado-Celis
ResearchOpen Access09 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Microfluidic-assisted analysis of replicating DNA molecules

Julia M Sidorova
Nianzhen Li
Raymond J Monnat Jr
Protocols14 May 2009
Nature Protocols

Volume: 4, P: 849-861

Search

The structure of I-Crel, a Group I intron-encoded homing endonuclease

Werner syndrome through the lens of tissue and tumour genomics

Cellular heterogeneity and therapeutic response profiling of human IDH + glioma stem cell cultures

Computational redesign of endonuclease DNA binding and cleavage specificity

DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI

The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites

A novel endonuclease mechanism directly visualized for I-PpoI

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

DNA polymerases and human disease

Werner and Hutchinson–Gilford progeria syndromes: mechanistic basis of human progeroid diseases

Whole-genome sequencing reveals host factors underlying critical COVID-19

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites

A first update on mapping the human genetic architecture of COVID-19

Tumour predisposition and cancer syndromes as models to study gene–environment interactions

Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype

Microfluidic-assisted analysis of replicating DNA molecules

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