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Showing 1–4 of 4 results
Advanced filters: Author: Rebeca Caires Clear advanced filters

  • Hyaluronan is a major component of the extracellular matrix, and is used to treat joint pain in osteoarthritis. In this study, Caires et al.show hyaluronan achieves its analgesic effects by targeting TRPV1 and stabilising the channel in its closed state.

    • Rebeca Caires
    • Enoch Luis
    • Elvira de la Peña
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Angelman syndrome (AS) is a neurogenetic disorder. Here, the authors found that PIEZO2 activity is reduced in sensory neurons from a mouse model of AS and used a linoleic acid-enriched diet to enhance PIEZO2 function and ameliorate AS-associated gait deficits.

    • Luis O. Romero
    • Rebeca Caires
    • Julio F. Cordero-Morales
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • PIEZO2 is a critical component of the mechanism by which innocuous touch causes pain (tactile allodynia). Here, authors find that the dietary fatty acid margaric acid decreases PIEZO2 function in a dose-dependent manner and counteracts neuronal mechanical sensitization by a proalgesic agent.

    • Luis O. Romero
    • Rebeca Caires
    • Valeria Vásquez
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12