Nature Search

Somatic evolution following cancer treatment in normal tissue

High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.

Oriol Pich
Sophia Ward
Nicholas McGranahan
ResearchOpen Access10 Dec 2025
Nature

P: 1-11
Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson’s disease

Here, the authors perform a machine learning meta-analysis of Parkinson’s disease (PD) classification based on microbiome features, showing that the accuracy of models can be generalizable and improve disease specificity when trained on multiple datasets, identifying PD-associated microbial pathways, including those involved in solvent and pesticide biotransformation.

Stefano Romano
Jakob Wirbel
Georg Zeller
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-17
Deep-sea mussels from a hybrid zone on the Mid-Atlantic Ridge host genetically indistinguishable symbionts

Merle Ücker
Rebecca Ansorge
Nicole Dubilier
ResearchOpen Access10 May 2021
The ISME Journal

Volume: 15, P: 3076-3083
Functional diversity enables multiple symbiont strains to coexist in deep-sea mussels

Using metagenomics and metatranscriptomics, up to 16 strains of intracellular, sulfur-oxidizing symbiotic bacteria were identified in individual mussels with different functions, indicating that high strain diversity is present in symbioses.

Rebecca Ansorge
Stefano Romano
Jillian Petersen
Research14 Oct 2019
Nature Microbiology

Volume: 4, P: 2487-2497
Lung adenocarcinoma promotion by air pollutants

Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

William Hill
Emilia L. Lim
Charles Swanton
Research05 Apr 2023
Nature

Volume: 616, P: 159-167
Copy number architectures define treatment-mediated selection of lethal prostate cancer clones

The heterogeneity of androgen receptor (AR) gene alterations across metastases in prostate cancer remains unresolved. Here, the authors characterise AR genomic complexity across spatially separated lethal metastases from 10 prostate cancer patients and investigate how AR alterations evolve.

A. M. Mahedi Hasan
Paolo Cremaschi
Gerhardt Attard
ResearchOpen Access10 Aug 2023
Nature Communications

Volume: 14, P: 1-16
Initial sequencing and analysis of the human genome

Eric S. Lander
Lauren M. Linton
Michael J. Morgan
articles01 Feb 2001
Nature

Volume: 409, P: 860-921
Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission

Catarina Cunha
John F. Smiley
Catia M. Teixeira
Research12 May 2020
Molecular Psychiatry

Volume: 26, P: 4795-4812
Horizontally transmitted symbiont populations in deep-sea mussels are genetically isolated

Devani Romero Picazo
Tal Dagan
Anne Kupczok
ResearchOpen Access08 Aug 2019
The ISME Journal

Volume: 13, P: 2954-2968
Inclusive science in the South Atlantic

The South Atlantic Meridional Overturning Circulation initiative began as a grassroots effort to study the South Atlantic Ocean and its impact on climate. This Comment discusses how, in striving towards this goal, it has also become a platform for the empowerment of women and international scientists.

Renellys Perez
Silvia Garzoli
Isabelle Ansorge
Comments & OpinionOpen Access19 Jan 2023
Communications Earth & Environment

Volume: 4, P: 1-5

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