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Showing 1–4 of 4 results
Advanced filters: Author: Rebecca Deasy Clear advanced filters

  • Loss-of-function CRISPR-based screens have identified several genes associated with cancer resistance to T cell-induced cytotoxicity. Here the authors perform a genome-scale, gain-of-function CRISPR screen and identify candidate genes, including the poly-N-acetyllactosamine synthase B3GNT2, whose overexpression confers tumor cell resistance to T cell cytotoxicity

    • Julia Joung
    • Paul C. Kirchgatterer
    • Feng Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Clear-cell carcinomas are aggressive tumours characterised by high accumulation of lipids and glycogen. Here, the authors report that these cancers have a common vulnerability to GPX4 inhibition-induced ferroptosis and using CRISPR screen and lipodomic profiling, they identify HIF-2α- HILPDA axis promotes ferroptosis via enrichment of PUFA lipids.

    • Yilong Zou
    • Michael J. Palte
    • Stuart L. Schreiber
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Depletion of the DNA helicase WRN induced double-stranded DNA breaks, and promoted apoptosis and cell cycle arrest selectively in cancers with microsatellite instability, indicating that WRN is a promising drug target for the treatment of these cancers.

    • Edmond M. Chan
    • Tsukasa Shibue
    • Adam J. Bass
    Research
    Nature
    Volume: 568, P: 551-556

  • Radiotherapy has attracted considerable attention as a means to alter the immune cell compartment of breast malignancies in support of increased sensitivity to immunotherapy. Recent data from Schalck and colleagues corroborate the notion that dose is a critical determinant of the immunological effects of radiotherapy on the tumor microenvironment.

    • Lorenzo Galluzzi
    • Lukas Bolini
    • Rebecca M. Shulman
    Comments & OpinionOpen Access
    npj Breast Cancer
    Volume: 11, P: 1-3