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Showing 1–16 of 16 results
Advanced filters: Author: Rebecca Heald Clear advanced filters

  • Understanding the effects of fast neutrons on high-temperature superconductors is important for their application in fusion reactors. Here, a combined experimental and theoretical study reveals that ion irradiation disrupts superconductivity by introducing defects within the copper-oxygen planes.

    • Rebecca J. Nicholls
    • Sofia Diaz-Moreno
    • Susannah C. Speller
    ResearchOpen Access
    Communications Materials
    Volume: 3, P: 1-14

  • In hybrid inviability between Xenopus laevis and Xenopus tropicalis, genomic regions on two X. laevis chromosomes are incompatible with the X. tropicalis cytoplasm and are mis-segregated during mitosis, leading to unbalanced gene expression at the maternal to zygotic transition, followed by cell-autonomous catastrophic embryo death.

    • Romain Gibeaux
    • Rachael Acker
    • Rebecca Heald
    Research
    Nature
    Volume: 553, P: 337-341

  • To celebrate almost 50 years from the discovery of tubulin, six eminent researchers reflect on how the field of microtubule research has advanced over the past five decades, discuss impacts on clinical translation, and provide their thoughts on what key questions need to be addressed in the near future.

    • Gary Borisy
    • Rebecca Heald
    • Eva Nogales
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 322-328

  • A fluorescence resonance energy transfer biosensor called Rango enables examination of the Ran–importin-β system in cells. Small changes in RanGTP concentration tip the balance between positive and negative mitotic regulators, thereby promoting spindle assembly and function.

    • Petr Kaláb
    • Arnd Pralle
    • Karsten Weis
    Research
    Nature
    Volume: 440, P: 697-701

  • Frogs are an ancient and ecologically diverse group of amphibians that include important model systems. This paper reports genome sequences of multiple frog species, revealing remarkable stability of frog chromosomes and centromeres, along with highly recombinogenic extended subtelomeres.

    • Jessen V. Bredeson
    • Austin B. Mudd
    • Daniel S. Rokhsar
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Some aerosol particles—known as ice nuclei—initiate ice formation in clouds, thereby influencing precipitation, cloud dynamics and incoming and outgoing solar radiation. Measurements of the concentration and elemental composition of ice nuclei in the Amazon basin indicate that local bioparticles and Saharan dust could explain the presence of almost all ice nuclei during the wet season.

    • Anthony J. Prenni
    • Markus D. Petters
    • Ulrich Pöschl
    Research
    Nature Geoscience
    Volume: 2, P: 402-405

  • Dense crowding of macromolecules in the cytoplasm is a fundamental property of cells. A study now identifies a pathway by which cytoplasmic dilution in differentiating neurons alters the morphology of the cell division apparatus, which likely contributes to proper neurodevelopment.

    • Gabriel Cavin-Meza
    • Rebecca Heald
    News & Views
    Nature Cell Biology
    Volume: 27, P: 884-885

  • Polθ has been recently identified as a therapeutic target in cancer but specific inhibitors are currently unavailable. Here, the authors identify small molecule inhibitors of Polθ’s polymerase activity which elicit BRCA1/2 synthetic lethality, enhance the effect of PARP inhibitors and target PARP inhibitor resistance caused by 53BP1/Shieldin pathway defects.

    • Diana Zatreanu
    • Helen M. R. Robinson
    • Christopher J. Lord
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • The two homoeologous subgenomes in the allotetraploid frog Xenopus laevis evolved asymmetrically; one often retained the ancestral state, whereas the other experienced gene loss, deletion, rearrangement and reduced gene expression.

    • Adam M. Session
    • Yoshinobu Uno
    • Daniel S. Rokhsar
    ResearchOpen Access
    Nature
    Volume: 538, P: 336-343

  • Accurate transmission of the genome during cell division requires the physical separation of replicated chromosomes. The identities of two molecular motors needed to do the job in fruitflies are now revealed.

    • Rebecca W. Heald
    News & Views
    Nature
    Volume: 427, P: 300-301

  • The goal of high-throughput screening (HTS) from the perspective of the biologist is to identify a highly specific small molecule that can be used to inhibit a protein in its normal biological context. Although several useful small molecules have been identified with HTS, there are many challenges to be considered when contemplating a screen, especially by those unfamiliar with chemical biology.

    • Jon Soderholm
    • Mike Uehara-Bingen
    • Rebecca Heald
    Comments & Opinion
    Nature Chemical Biology
    Volume: 2, P: 55-58