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Showing 1–4 of 4 results
Advanced filters: Author: Rebecca L Pollex Clear advanced filters

  • In addition to environmental factors, genetic variation exerts a sizeable, complex influence on lipoprotein phenotypes. Rebecca Pollex and Robert Hegele review recent progress on genomic variants and cholesterol metabolism, focusing on key, well-characterized genes that are determinants of plasma lipoproteins and have shown consistent results over the years, and discuss their potential utility in clinical cardiology.

    • Rebecca L Pollex
    • Robert A Hegele
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 4, P: 600-609

  • A single definition for the metabolic syndrome is not forthcoming since discussion of its forms and causes is continuing. Genetic causes and onset of the syndrome in relation to triggering genetic–environment interactions have been suggested. In this Review, the currently available knowledge about the most common purported genetic causes is drawn together.

    • Rebecca L Pollex
    • Robert A Hegele
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 3, P: 482-489

  • Analysis of enhancer–promoter (E–P) interactions during Drosophila embryogenesis suggests that the relationship between E–P proximity and activity depends on the developmental stage. Increased E–P proximity is associated with activity during differentiation but not specification.

    • Tim Pollex
    • Adam Rabinowitz
    • Eileen E. M. Furlong
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 686-696

  • Several known candidate gene variants are useful markers for diagnosing hyperlipoproteinemia. In this paper the authors evaluate the association of two commonAPOA5 single-nucleotide polymorphisms across the range of classic hyperlipoproteinemia phenotypes. Their data shows that a high proportion of patients with four classic hyperlipoproteinemia phenotypes are carriers of either the APOA5S19W or −1131T>C variant or both. The authors conclude that these two variants are robust genetic biomarkers of a range of clinical hyperlipoproteinemia phenotypes linked by hypertriglyceridemia.

    • Jian Wang
    • Matthew R Ban
    • Robert A Hegele
    Research
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 5, P: 730-737