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Showing 1–18 of 18 results
Advanced filters: Author: Rebecca Schulman Clear advanced filters

  • Biosensors that accurately detect proteins are critical for biological applications, but modular transduction of binding into useful outputs is a challenge. Here, authors develop a modular platform using aptamer-regulated transcription to detect proteins and process RNA outputs via molecular circuits.

    • Heonjoon Lee
    • Tian Xie
    • Rebecca Schulman
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Using chemical reactions and diffusion to control pattern formation requires the careful design of reaction networks and a balance of kinetics that is difficult to achieve. Now, it has been shown that DNA-based reaction networks provide a robust method for transforming patterns.

    • Dominic Scalise
    • Rebecca Schulman
    News & Views
    Nature Chemistry
    Volume: 5, P: 986-987

  • Shape transformation without the need for external devices or wires is desirable for soft robotics, but challenging to achieve. Here, the authors report the development of actuators capable of shape changes by polymerization and depolymerization of DNA activator sequences.

    • Ruohong Shi
    • Kuan-Lin Chen
    • Rebecca Schulman
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Synthetic chemical networks with far-from-equilibrium dynamics akin to genetic regulatory networks in living cells could precisely regulate the kinetics of chemical synthesis or self-assembly. Now standardized excitable chemical regulatory elements, termed genelets, that enable predictive bottom-up construction of in vitro networks with designed temporal and multistable behaviour have been developed.

    • Samuel W. Schaffter
    • Kuan-Lin Chen
    • Rebecca Schulman
    Research
    Nature Chemistry
    Volume: 14, P: 1224-1232

  • Materials which change shape in response to a trigger are of interest for soft robotics and targeted therapeutic delivery. Here, the authors report on the development of DNA-crosslinked hydrogels which can expand upon the detection of different biomolecular inputs mediated by DNA strand-displacement.

    • Joshua Fern
    • Rebecca Schulman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8

  • Gaining control over crystallization processes is challenging. Herein, the authors describe a protocol for the controlled growth of DNA nanotubes by feedback regulation: the coupling of a reversible bimolecular monomer buffering reaction delivers the optimal monomer concentration and leads to reliable crystal growth in a simple manner.

    • Samuel W. Schaffter
    • Dominic Scalise
    • Rebecca Schulman
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Vicine and convicine are the main anti-nutritional factors restricting the consumption of faba bean. Transcript profiling combined with metabolite profiling was applied to identify a key enzyme responsible for the biosynthesis of vicine and convicine in faba bean.

    • Emilie Björnsdotter
    • Marcin Nadzieja
    • Fernando Geu-Flores
    Research
    Nature Plants
    Volume: 7, P: 923-931

  • One goal of synthetic biologists is to develop artificial systems to help study biological processes. Now, cell communication and differentiation have been demonstrated using spatiotemporal patterns created in artificial multicellular compartments.

    • Yi Li
    • Rebecca Schulman
    News & Views
    Nature Chemistry
    Volume: 11, P: 18-20

  • A molecular reaction network translated from a computer-trained classifier can distinguish lung cancer patients from healthy individuals based on specific microRNAs in the blood.

    • Pepijn G. Moerman
    • Rebecca Schulman
    News & Views
    Nature Nanotechnology
    Volume: 15, P: 626-627

  • The regulation of cellular response to stimuli by genetic regulatory networks (GRNs) suggests how in vitro chemical reaction networks might be used to direct the dynamics of synthetic materials or chemical reactions. Now, multiple functional in vitro transcriptional circuit modules have been integrated to form composite regulatory networks capable of complex features analogous to those found in cellular GRNs.

    • Samuel W. Schaffter
    • Rebecca Schulman
    Research
    Nature Chemistry
    Volume: 11, P: 829-838

  • The transcription cofactor CBF-β is shown to regulate the ability of HIV-1 to evade host restriction mediated by the deaminase APOBEC3; it acts by interacting with the HIV protein Vif, so disrupting the Vif–CBF-β interaction could provide a new therapeutic target against HIV-1 infection.

    • Stefanie Jäger
    • Dong Young Kim
    • Nevan J. Krogan
    Research
    Nature
    Volume: 481, P: 371-375

  • This Perspective reviews the complementary developments in synthetic biology and biomaterials and discusses how convergence of these two fields creates a promising design strategy for the fabrication of tailored living materials for medicine and biotechnology.

    • Allen P. Liu
    • Eric A. Appel
    • Ovijit Chaudhuri
    Reviews
    Nature Materials
    Volume: 21, P: 390-397