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Showing 1–4 of 4 results
Advanced filters: Author: Rebecca Yunker Clear advanced filters

  • The fungus Candida albicans is ubiquitous and usually harmless in the human gut, but can also cause systemic infection. Here, Kakade et al. show that fungal secretion of an immunomodulatory toxin, candidalysin, activates a host IL-17-DUOX2 axis that regulates C. albicans colonization of the intestine.

    • Pallavi Kakade
    • Juan F. Burgueno
    • Richard J. Bennett
    ResearchOpen Access
    Nature Communications
    P: 1-15

  • High-throughput DNA or RNA labelling with optimized Oligopaints (HiDRO) reveals more than 300 factors that influence genome folding during interphase, including 43 genes that were validated as either increasing or decreasing interactions between topologically associating domains.

    • Daniel S. Park
    • Son C. Nguyen
    • Eric F. Joyce
    Research
    Nature
    Volume: 620, P: 209-217

  • A combination of super-resolution microscopy and Oligopaint technology shows that TAD boundaries are variable at the single-cell level. Loss of cohesin, in contrast to WAPL or CTCF depletion, reduces interactions across boundaries and alters transcriptional bursting of genes near boundaries.

    • Jennifer M. Luppino
    • Daniel S. Park
    • Eric F. Joyce
    Research
    Nature Genetics
    Volume: 52, P: 840-848