ILCs are considered preformed effector cells. Gasteiger and colleagues report that ILC1s undergo effector differentiation after lineage commitment. Hobit+ ILC1s emerge as cKit+TCF-1hi cells that generate tissue-specific helper- and cytotoxic-like cells along a Hobit-dependent trajectory.
- Christin Friedrich
- Renske L. R. E. Taggenbrock
- Georg Gasteiger
