Nature Search

RING1 missense variants reveal sensitivity of DNA damage repair to H2A monoubiquitination dosage during neurogenesis

Here, the authors establish a human in vitro model of neurodevelopment to investigate an allelic series of clinically relevant RING1 and RNF2 missense variants. The observations reveal that missense variants function according to a dominant-negative genetic mechanism.

C. W. Ryan
S. L. Regan
S. L. Bielas
ResearchOpen Access10 Sept 2024
Nature Communications

Volume: 15, P: 1-20
Isotopic evidence for elevated photorespiration during the last glacial period

Low carbon dioxide levels during the last glacial period enhanced photorespiration in trees across North America, indicating a decline in land plant productivity, according to measurements of clumped isotopes in subfossil wood samples.

Max K. Lloyd
Rebekah S. Sprengel
Daniel A. Stolper
Research05 Nov 2025
Nature Geoscience

Volume: 18, P: 1232-1238
A CAR enhancer increases the activity and persistence of CAR T cells

Chimeric antigen receptor T cell efficacy is enhanced with an interleukin 2-recruiting molecule.

Taha Rakhshandehroo
Shreya R. Mantri
Mohammad Rashidian
Research30 Jul 2024
Nature Biotechnology

Volume: 43, P: 948-959
Effect of Treatment with Prostaglandin Synthetase Inhibitors on the Erythrocyte Sodium Transport Abnormality of Bartter's Syndrome

C H Cole
S O'regan
Research01 Jun 1981
Pediatric Research

Volume: 15, P: 926-929
Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy

Genome-wide association analyses comprising 14,256 cases and 1,199,156 controls and incorporating correlated cardiac magnetic resonance imaging traits provide insights into the molecular etiology of dilated cardiomyopathy.

Sean L. Zheng
Albert Henry
R. Thomas Lumbers
ResearchOpen Access21 Nov 2024
Nature Genetics

Volume: 56, P: 2646-2658
Decoupling the spread of grasslands from the evolution of grazer-type herbivores in South America

It has been thought that the evolution of mammals similar to modern grass-eating horses in South America ∼38 million years ago was a response to the spread of grasslands. This study uses microscopic plant silica fossils from southern Argentina to show that these presumed grass-eating mammals evolved in forests, not grasslands.

Caroline A.E. Strömberg
Regan E. Dunn
Alfredo A. Carlini
Research12 Feb 2013
Nature Communications

Volume: 4, P: 1-8
Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders

Neurodevelopmental disorders (NDDs) are a heterogeneous group of diseases for which the genetic basis is still unknown in more than half of the cases. Here, the authors report a NDD associated with disruptive variants in the TANC2 gene and show that rols, the TANC2 homolog in flies, is required for synapse growth and function.

Hui Guo
Elisa Bettella
Evan E. Eichler
ResearchOpen Access15 Oct 2019
Nature Communications

Volume: 10, P: 1-17
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Intercalation events visualized in single microcrystals of graphite

The common lithium-ion battery is re-charged by intercalating its graphite anode, but intercalation remains not well understood. Electron microscope video of intercalating graphite microcrystals reveals that the charge transfer occurs in current pulses that do not match theoretical expectations.

Edward R. White
Jared J. Lodico
B. C. Regan
ResearchOpen Access06 Dec 2017
Nature Communications

Volume: 8, P: 1-9
RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling

Vascular inflammation plays a key role in pathogenesis of major vascular diseases. Here the authors show that Regulator of G-Protein Signaling-1 (RGS1) controls macrophage function in the development of vascular inflammation that underlies atherosclerosis and abdominal aortic aneurysms in mice and humans.

Jyoti Patel
Eileen McNeill
Keith M. Channon
ResearchOpen Access18 Mar 2015
Nature Communications

Volume: 6, P: 1-11
A genome-wide analysis of the response to inhaled β₂-agonists in chronic obstructive pulmonary disease

M Hardin
M H Cho
J Yates
Research27 Oct 2015
The Pharmacogenomics Journal

Volume: 16, P: 326-335
Three-dimensional imaging of dislocations in a nanoparticle at atomic resolution

A new combination of established techniques is used to produce three-dimensional (3D) images and a video of almost all the atoms in a platinum nanoparticle, revealing the 3D core structure of edge and screw dislocations and 3D twin boundaries in the nanoparticle at atomic resolution.

Chien-Chun Chen
Chun Zhu
Jianwei Miao
Research27 Mar 2013
Nature

Volume: 496, P: 74-77
Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

J Bluett
I Ibrahim
A Barton
ResearchOpen Access16 Jul 2013
The Pharmacogenomics Journal

Volume: 14, P: 171-175

Search

RING1 missense variants reveal sensitivity of DNA damage repair to H2A monoubiquitination dosage during neurogenesis

Isotopic evidence for elevated photorespiration during the last glacial period

A CAR enhancer increases the activity and persistence of CAR T cells

Effect of Treatment with Prostaglandin Synthetase Inhibitors on the Erythrocyte Sodium Transport Abnormality of Bartter's Syndrome

Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy

Decoupling the spread of grasslands from the evolution of grazer-type herbivores in South America

Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Intercalation events visualized in single microcrystals of graphite

RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling

A genome-wide analysis of the response to inhaled β₂-agonists in chronic obstructive pulmonary disease

Three-dimensional imaging of dislocations in a nanoparticle at atomic resolution

Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

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