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Showing 1–2 of 2 results
Advanced filters: Author: Reggy Ekkebus Clear advanced filters

  • Deubiquitinating enzymes (DUBs) are critical regulators of cellular processes by removing ubiquitin from specific targets. Here global kinetic modelling reveals the mechanism by which the low intrinsic activity of USP7 is substantially enhanced on a specific physiological target.

    • Robbert Q. Kim
    • Paul P. Geurink
    • Titia K. Sixma
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • The tumor suppressor BAP1 is activated by ASXL1 to deubiquitinate mono-ubiquitinated H2A at K119 in Polycomb gene repression. Here, the authors show how BAP1’s C-terminal extension auto-recruits it to nucleosomes, where the DEUBAD domain of ASXL1 increases BAP1’s affinity for ubiquitin to drive deubiquitination.

    • Danny D. Sahtoe
    • Willem J. van Dijk
    • Titia K. Sixma
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13