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Showing 1–9 of 9 results
Advanced filters: Author: Regina R. Reimann Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • The H-latch is a well-defined structural change occurring in PrPC bound to the neurotoxic antibody POM1, and its presence shows a positive correlation with neurotoxicity. Inhibition of the H-latch prolongs the lifespan of prion-diseased mice.

    • Karl Frontzek
    • Marco Bardelli
    • Adriano Aguzzi
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 831-840

  • Results from a study of five patients with refractory systemic lupus erythematosus, who were treated with anti-CD19 CAR T cell therapy under a compassionate-use program, demonstrate remission of SLE disease with follow-up of up to 17 months.

    • Andreas Mackensen
    • Fabian Müller
    • Georg Schett
    Research
    Nature Medicine
    Volume: 28, P: 2124-2132

  • Christer Betsholtz, Christine Klein, Maria Sobrido and colleagues report the identification of mutations in the gene encoding PDGF-B that cause idiopathic basal ganglia calcification. They also show that mice carrying hypomorphic Pdgfb alleles develop brain calcifications.

    • Annika Keller
    • Ana Westenberger
    • Joao R M Oliveira
    Research
    Nature Genetics
    Volume: 45, P: 1077-1082

  • Geoffrey Woods, Jan Senderek and colleagues show that biallelic mutations in PRDM12 cause congenital insensitivity to pain. They further show that PRDM12 is expressed in nociceptors and their progenitors and participates in sensory neuron development in Xenopus.

    • Ya-Chun Chen
    • Michaela Auer-Grumbach
    • Jan Senderek
    Research
    Nature Genetics
    Volume: 47, P: 803-808