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Showing 1–11 of 11 results
Advanced filters: Author: Rei Matsuoka Clear advanced filters

  • Pseudomonas aeruginosa survives extreme acidity by importing lysine through the LysP transporter to regulate acid-resistance genes. Here, authors reveal the cryo-EM structure of LysP and show how specific hydrogen bonds enable lysine recognition.

    • Deniz Bicer
    • Rei Matsuoka
    • Emmanuel Nji
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • Na+ /H+ exchangers regulate intracellular pH, sodium levels, and cell volume. Cryo-EM structures reveal lipid coordination at the dimer interfaces of NhaA with cardiolipin and endosomal NHE9 with PI(3,5)P2. These findings demonstrate how specific lipids can regulate ion-exchange activity by stabilizing dimerization with physiological ramifications.

    • Surabhi Kokane
    • Ashutosh Gulati
    • David Drew
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • NHA2 exchanges sodium ions for protons across cell membranes, and its activity is linked to the pathogenesis of diabetes mellitus and essential hypertension in humans. Drew et al. report the cryo-EM structure of NHA2 in detergent and nanodiscs.

    • Rei Matsuoka
    • Roman Fudim
    • David Drew
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 108-120

  • Intracellular potassium (K+) homeostasis is achieved by activity of both ion channels and transporters. Here, the authors report structures of E. coli glutathione (GSH)-gated K+ efflux transporter KefC with bound K+ and conclude that the ion-binding site is adapted for binding a dehydrated ion.

    • Ashutosh Gulati
    • Surabhi Kokane
    • David Drew
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Crystal structure of the Plasmodium falciparum hexose transporter PfHT1 reveals the molecular basis of its ability to transport multiple types of sugar as efficiently as the dedicated mammalian glucose and fructose transporters.

    • Abdul Aziz Qureshi
    • Albert Suades
    • David Drew
    Research
    Nature
    Volume: 578, P: 321-325

  • Mutations in the ankyrin repeat domain (ARD) of TRPV4 are responsible for several channelopathies but little is known about the physiological function of this domain. Here the authors show that phosphoinositide binding to TRPV4 ARD leads to suppression of the channel activity, and obtain the crystal structure of the domain in complex with inositol-1,4,5-trisphosphate.

    • Nobuaki Takahashi
    • Sayaka Hamada-Nakahara
    • Shiro Suetsugu
    Research
    Nature Communications
    Volume: 5, P: 1-15

  • Ieki et al. train a deep learning model to estimate patients’ age from chest X-ray images. X-ray age is found to be an indicator of poor prognosis in patients with heart failure and patients admitted to the intensive care unit with cardiovascular disease.

    • Hirotaka Ieki
    • Kaoru Ito
    • Issei Komuro
    ResearchOpen Access
    Communications Medicine
    Volume: 2, P: 1-12

  • Ylla, Extavour et al. use genomic data from crickets to investigate the evolution of large genome sizes and DNA methylation events in insects. Their findings indicate that transposable element activity drove genome expansion in hemimetabolous insects, such as crickets and grasshoppers, and that DNA methylation is predominant in conserved genes.

    • Guillem Ylla
    • Taro Nakamura
    • Cassandra G. Extavour
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12