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Showing 1–3 of 3 results
Advanced filters: Author: Rejean L. Wang Clear advanced filters

  • Ubiquitination may control protein stability or function. Here the authors show that an ubiquitination enzyme, Hectd3, ubiquitinates Stat3 and Malt1 to modulate their function but not degradation in T cells, and thereby promoting the differentiation of pathogenic Th17 cells and susceptibility to a mouse model of multiple sclerosis.

    • Jonathan J. Cho
    • Zhiwei Xu
    • Dorina Avram
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18

  • The treatment of immune-related adverse events (irAEs) in patients receiving immune checkpoint inhibitors has mostly been based on adapting therapeutic approaches used in the management of primary autoimmune diseases. The authors of this Review provide an overview of the different cellular and soluble immune factors involved in the pathogenesis of irAEs in order to help clinicians deliver personalized immunopathologically guided treatment to manage these adverse events.

    • Khashayar Esfahani
    • Arielle Elkrief
    • Leonard Calabrese
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 17, P: 504-515