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Showing 1–6 of 6 results
Advanced filters: Author: René Platzer Clear advanced filters

  • Determining molecular clustering in Photoactivated Localization Microscopy (PALM) experiments requires knowledge of the blinking properties of the fluorophore to prevent overcounting artefacts. Here the authors develop an experimental and analytical framework to determine the blinking parameters of fluorophores and incorporate this information into cluster analysis.

    • René Platzer
    • Benedikt K. Rossboth
    • Mario Brameshuber
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Mechanical forces at the immunological synapse are believed to influence antigen recognition by the T cell receptor (TCR). Here the authors analyse these forces at single-molecule resolution to show that the ligand-engaged TCR of CD4+ T-cells create a stable environment with only a small fraction of TCR:pMHC complexes experiencing mechanistic forces at any given time during antigen surveillance and upon T-cell activation.

    • Lukas Schrangl
    • Florian Kellner
    • Janett Göhring
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Stepanek and colleagues demonstrate that the LCK kinase associated with CD4 or CD8 co-receptors has kinase-dependent and kinase-independent roles in T cell activation.

    • Veronika Horkova
    • Ales Drobek
    • Ondrej Stepanek
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 174-185

  • Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their sensitivity and specificity are still poorly defined. Here, authors report a FRET-based sensor that informs directly on the magnitude and kinetics of TCR-imposed forces at the single molecule level.

    • Janett Göhring
    • Florian Kellner
    • Gerhard J. Schütz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Boztug and colleagues identify an immunodeficient patient with a deficiency in the guanine-nucleotide-exchange factor RASGRP1. They find that human RASGRP1 is important for the function of T cells, B cells and NK cells and that it has a role in the regulation of the cytoskeleton.

    • Elisabeth Salzer
    • Deniz Cagdas
    • Kaan Boztug
    Research
    Nature Immunology
    Volume: 17, P: 1352-1360