Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–15 of 15 results
Advanced filters: Author: Renato Ostuni Clear advanced filters

  • Anti-tumor functions of low-avidity T cells are often suboptimal. Here the authors show that genetic disruption of TIGIT in TCR-engineered T cells enhances their anti-tumor activity against pancreatic and other gastrointestinal cancers by increasing TCR signal strength.

    • Martina Spiga
    • Alessia Potenza
    • Chiara Bonini
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • A blood single-cell atlas of human sepsis identifies subsets of immune-suppressive neutrophils in people at high risk.

    • Roza Maria Barouni
    • Renato Ostuni
    News & Views
    Nature Immunology
    Volume: 24, P: 746-748

  • In this Review, Natoli and Ostuni discuss the mechanisms of adaptation and memory in immunity, with the aim of providing basic concepts that rationalize the properties and molecular bases of these essential processes.

    • Gioacchino Natoli
    • Renato Ostuni
    Reviews
    Nature Immunology
    Volume: 20, P: 783-792

  • Recent studies suggest that neutrophils can exhibit substantial function diversity. Here, Ostuni and colleagues perform immunophenotyping and transcriptome analysis to characterize the heterogeneity of human neutrophils, both under steady state and upon stress-induced conditions.

    • Elisa Montaldo
    • Eleonora Lusito
    • Renato Ostuni
    Research
    Nature Immunology
    Volume: 23, P: 1470-1483

  • Single-cell and spatial gene expression analyses of pancreatic ductal adenocarcinoma uncover a population of interleukin-1β-expressing macrophages that drive inflammatory reprogramming of neighboring tumour cells leading to disease progression and poor prognosis for patients.

    • Nicoletta Caronni
    • Federica La Terza
    • Renato Ostuni
    Research
    Nature
    Volume: 623, P: 415-422

  • Liver metastases are a clinical problem, with low responses to immunotherapy. Here, authors coordinate expression of tumor antigens IFNα and IL-12 in liver and tumor associated macrophages to rejuvenate tumor reactive T cells and eliminate liver metastases.

    • Marco Notaro
    • Maristella Borghetti
    • Mario Leonardo Squadrito
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-24

  • Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1). Here the authors show that the loss of TIM4 expression in lung tumor associated cDC1 is associated with less efficient uptake of cell associated antigens and reduction of CD8 + T cell activation in advanced lung tumors.

    • Nicoletta Caronni
    • Giulia Maria Piperno
    • Federica Benvenuti
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • How IL-6 expression is regulated in human neutrophils has remained unclear. Here the authors show, using highly purified neutrophils, that TLR8 or TLR4 signalling activates latent enhancers and cooperates with autocrine TNFα to induce IL-6transcription.

    • Maili Zimmermann
    • Francisco Bianchetto Aguilera
    • Marco A. Cassatella
    Research
    Nature Communications
    Volume: 6, P: 1-14

  • An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα  reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell responses.

    • Giulia Escobar
    • Luigi Barbarossa
    • Luigi Naldini
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Emerging data indicate that neutrophils exist in several different ‘flavours’. Here, the authors outline potential underlying mechanisms for the presence of distinct neutrophil subsets in health and disease.

    • Lai Guan Ng
    • Renato Ostuni
    • Andrés Hidalgo
    Reviews
    Nature Reviews Immunology
    Volume: 19, P: 255-265

  • Here, CD14 is shown to regulate mouse dendritic cell apoptosis after lipopolysaccharide stimulation via a pathway involving activation of the transcription factor NFAT; an event that is essential for maintaining self-tolerance and preventing autoimmunity. Given the involvement of CD14 in diseases such as sepsis and heart failure, the discovery of signal transduction pathways activated exclusively by CD14 is an important step towards the development of potential new treatments.

    • Ivan Zanoni
    • Renato Ostuni
    • Francesca Granucci
    Research
    Nature
    Volume: 460, P: 264-268