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Showing 1–4 of 4 results
Advanced filters: Author: Rene Goliath Clear advanced filters

  • Here the authors describe outcomes of SARS-CoV-2 infection in an African setting of high HIV-1 and tuberculosis prevalence. They find that tuberculosis is a common co-morbidity in patients admitted to hospital with COVID-19 and that the immune response to SARS-CoV-2 is adversely affected by co-existent HIV-1 and tuberculosis.

    • Elsa du Bruyn
    • Cari Stek
    • Robert J. Wilkinson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Some patients with HIV-associated tuberculosis develop an immune reconstitution inflammatory syndrome (TB-IRIS) in response to antiretroviral therapy. Here the authors identify genes differentially expressed in patients likely to progress to TB-IRIS and find activation of Toll-like receptor and inflammasome pathways.

    • Rachel P. J. Lai
    • Graeme Meintjes
    • Robert J. Wilkinson
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Tarpey et al. carry out a large-scale systematic sequencing of the majority of X-chromosome coding exons from 208 families with multiple individuals with mental retardation and a pattern of transmission compatible with X linkage in order to identify XLMR-causative mutations. They find several mutations that appear to be causative in loci already known to be involved in XLMR, as well as new data about those loci, and make inferences about the role of the different classes of variants in these diseases.

    • Patrick S Tarpey
    • Raffaella Smith
    • Michael R Stratton
    Research
    Nature Genetics
    Volume: 41, P: 535-543