Nature Search

Structural basis for catalysis and substrate specificity of human ACAT1

The structure of human ACAT1, which catalyses the transfer of an acyl group from acyl-coenzyme A to cholesterol to form cholesteryl ester, is resolved by cryo-electron microscopy.

Hongwu Qian
Xin Zhao
Nieng Yan
Research13 May 2020
Nature

Volume: 581, P: 333-338
Cryo-EM structure of the human Asc-1 transporter complex

The human Asc-1-4F2hc complex plays an important role in the neural development and stability. Here, authors determine the cryo-EM structures of Asc-1-4F2hc complex in three states, revealing its substrate recognition and transport mechanism.

Yaning Li
Yingying Guo
Renhong Yan
ResearchOpen Access08 Apr 2024
Nature Communications

Volume: 15, P: 1-10
Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states

Sodium-Potassium Pump (Na⁺/K⁺-ATPase, NKA) generates an electrochemical gradient of sodium and potassium ions across the plasma membrane by hydrolyzing ATP. Here, the authors report structures of human NKA providing insight into the cytoplasmic Na⁺ entrance and the cytoplasmic gate closure coupled to ATP hydrolysis.

Yingying Guo
Yuanyuan Zhang
Qiang Zhou
ResearchOpen Access08 Jul 2022
Nature Communications

Volume: 13, P: 1-9
Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir

In this study, the authors report the structure-based discovery and preclinical evaluation of 2 simnotrelvir, an orally bioavailable 3CLpro inhibitor that blocks replication of SARS-CoV-2 variants in 3 vitro, shows robust efficacy in a mouse model and good safety and pharmacokinetic profiles in rats 4 and monkeys.

Xiangrui Jiang
Haixia Su
Yechun Xu
ResearchOpen Access13 Oct 2023
Nature Communications

Volume: 14, P: 1-15
The complete assembly of human LAT1-4F2hc complex provides insights into its regulation, function and localisation

The amino acid transporter complex LAT1-4F2hc is considered a major drug target for many cancers. Here, the authors apply native mass spectrometry-based approaches to decode a complete LAT1-4F2hc assembly. To do this, they connect post-translational modification and endogenous phospholipid binding to super-dimerization, function and localisation of LAT1-4F2hc.

Di Wu
Renhong Yan
Carol V. Robinson
ResearchOpen Access02 May 2024
Nature Communications

Volume: 15, P: 1-12
Structural basis for the evolution and antibody evasion of SARS-CoV-2 BA.2.86 and JN.1 subvariants

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

Haonan Yang
Huimin Guo
Zheng Zhang
ResearchOpen Access04 Sept 2024
Nature Communications

Volume: 15, P: 1-14
Molecular basis of inhibition of the amino acid transporter B⁰AT1 (SLC6A19)

A block of B⁰AT1 (SLC6A19) can be used to treat rare disorders of amino acid metabolism. Here Xu and colleagues employed a medicinal chemistry approach to generate B⁰AT1 inhibitors and show their binding by high-resolution cryo-electron microscopy.

Junyang Xu
Ziwei Hu
Stefan Bröer
ResearchOpen Access22 Aug 2024
Nature Communications

Volume: 15, P: 1-10
The cryo-EM structure of homotetrameric attachment glycoprotein from langya henipavirus

In this work, the authors report the full-length structure of the attachment glycoprotein from Langya Henipavirus, which could enhance the understanding of emerging Henipavirus and provide important clues for vaccine development in the future.

Yingying Guo
Songyue Wu
Renhong Yan
ResearchOpen Access27 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox virus

Here, using structural and biochemical data, the authors revealed the assembly and working mechanism of helicase-primase D5 from Mpox virus.

Yaning Li
Jing Zhu
Renhong Yan
Research04 Jan 2024
Nature Structural & Molecular Biology

Volume: 31, P: 68-81
Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter

Renhong Yan
Yaning Li
Qiang Zhou
ResearchOpen Access23 Mar 2021
Cell Discovery

Volume: 7, P: 1-8
Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2

A broad-range human antibody with neutralizing activity against various coronaviruses, including SARS-CoV-2, targets a unique epitope within the highly conserved S2’ site and the fusion peptide of the spike protein that is exposed during interaction with the host cell. The pan-coronavirus antibody protects mice against infection with SARS-CoV-2 and HCoV-OC43 following prophylactic and therapeutic treatment.

Xiaoyu Sun
Chunyan Yi
Bing Sun
Research30 Jun 2022
Nature Microbiology

Volume: 7, P: 1063-1074
Sodium nitrate protects against metabolic syndrome by sialin-mediated macrophage rebalance

Shaorong Li
Yaning Wang
Songlin Wang
ResearchOpen Access02 Oct 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-21
Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex

The cryo-EM structure of the LAT1–4F2hc complex, a heteromeric amino acid transporter, is characterized, providing insights into its function and the mechanisms through which mutations of this complex could cause disease.

Renhong Yan
Xin Zhao
Qiang Zhou
Research13 Mar 2019
Nature

Volume: 568, P: 127-130
Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2

Renhong Yan
Yuanyuan Zhang
Qiang Zhou
ResearchOpen Access18 Mar 2021
Cell Research

Volume: 31, P: 717-719
Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies

Renhong Yan
Ruoke Wang
Qiang Zhou
ResearchOpen Access17 Mar 2021
Cell Research

Volume: 31, P: 517-525
ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker

Yuning Chen
Ya-Nan Zhang
Chunhe Wang
ResearchOpen Access25 Aug 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-9
The crucial role of neutrophil extracellular traps and IL-17 signaling in indomethacin-induced gastric injury in mice

Yujun Hou
Wen Wang
Ying Li
ResearchOpen Access09 Apr 2025
Scientific Reports

Volume: 15, P: 1-18
The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis

Renhong Yan
Enjun Xie
Fudi Wang
CorrespondenceOpen Access29 Mar 2022
Cell Research

Volume: 32, P: 687-690
Structural insight into the substrate recognition and transport mechanism of the human LAT2–4F2hc complex

Renhong Yan
Jiayao Zhou
Qiang Zhou
CorrespondenceOpen Access10 Nov 2020
Cell Discovery

Volume: 6, P: 1-4
Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection

Liang Guo
Wenwen Bi
Bobo Dang
Correspondence11 Nov 2020
Cell Research

Volume: 31, P: 98-100
Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses

Yingdan Wang
Meiqin Liu
Jinghe Huang
ResearchOpen Access21 Apr 2022
Cell Discovery

Volume: 8, P: 1-16
Structural basis for the inhibition mechanism of LAT1-4F2hc complex by JPH203

Ziwei Hu
Renhong Yan
CorrespondenceOpen Access02 Jul 2024
Cell Discovery

Volume: 10, P: 1-3
Cryo-EM structures of SARS-CoV-2 BA.2-derived subvariants spike in complex with ACE2 receptor

Yaning Li
Chang Ren
Renhong Yan
CorrespondenceOpen Access02 Nov 2023
Cell Discovery

Volume: 9, P: 1-4
Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B⁰AT1 and ACE2-SIT1

Yaning Li
Yiming Chen
Renhong Yan
CorrespondenceOpen Access08 Sept 2023
Cell Discovery

Volume: 9, P: 1-5
Structures of ACE2–SIT1 recognized by Omicron variants of SARS-CoV-2

Yaping Shen
Jianhui Wang
Renhong Yan
CorrespondenceOpen Access16 Nov 2022
Cell Discovery

Volume: 8, P: 1-4

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