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Optimized in vivo base editing restores auditory function in a DFNA15 mouse model

Genetic mutations causing hereditary deafness, including autosomal dominant non-syndromic deafness 15 (DFNA15), currently have no effective treatment. Here, authors establish a Pou4f3^WT/Q113* mutant mouse model and engineer and deliver an adenine base editor for near-complete hearing recovery.

Man Wang
Ziyu Zhang
Renjie Chai
ResearchOpen Access18 Sept 2025
Nature Communications

Volume: 16, P: 1-15
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition

Cui, Guo, Liu et al. identify a bacterial species, Peptostreptococcus anaerobius, in the gut that produces a tryptophan metabolite and engages intracellular pathways to modulate ferroptosis-suppressor protein 1 activity, thereby suppressing ferroptosis and promoting colorectal cancer development.

Weiwei Cui
Meng Guo
Bo Chu
Research02 Jan 2024
Nature Cell Biology

Volume: 26, P: 124-137
Probing the crystallographic orientation of two-dimensional atomic crystals with supramolecular self-assembly

Identifying the crystallographic orientations of 2D materials is important, but methods to do so are typically destructive. Here, the authors show that the orientational dependency of self-assembled nanoribbons of oleamide molecules can be used to non-invasively probe the lattice orientations of various 2D substrates.

Jinghui Wang
Hongde Yu
Liying Jiao
ResearchOpen Access29 Aug 2017
Nature Communications

Volume: 8, P: 1-8
The correlation between serum sex hormone levels and clear cell renal cell carcinoma in male patients

Zhongwei Yu
Chenhui Zhao
Tao Huang
ResearchOpen Access01 Mar 2025
Scientific Reports

Volume: 15, P: 1-5
Tumor-resident Malassezia can promote hepatocellular carcinoma development by downregulating bile acid synthesis and modulating tumor microenvironment

Weixi Shen
Zhihong Li
Lei Ji
ResearchOpen Access29 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
Controllable Thermal Rectification Realized in Binary Phase Change Composites

Renjie Chen
Yalong Cui
Ruqiang Zou
ResearchOpen Access09 Mar 2015
Scientific Reports

Volume: 5, P: 1-8
Table tennis motion recognition based on the bat trajectory using varying-length-input convolution neural networks

Jun Zhang
Yuanshi Ren
Jie Ren
ResearchOpen Access12 Feb 2024
Scientific Reports

Volume: 14, P: 1-8
Study on the energy evolution mechanism of coal and rock with impact tendency under different strain rates

Kun Zhang
Yichen Zhang
Yuanquan Cui
ResearchOpen Access23 Aug 2023
Scientific Reports

Volume: 13, P: 1-12
Structural insights into ribonucleoprotein dissociation by nucleocapsid protein interacting with non-structural protein 3 in SARS-CoV-2

Reporting the crystal structure of the N-terminal domain of the viral nucleocapsid protein in complex with the ubiquitin-like domain 1 of Nsp3 in SARS-CoV-2

Xincheng Ni
Yinze Han
Jian Lei
ResearchOpen Access18 Feb 2023
Communications Biology

Volume: 6, P: 1-12

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Optimized in vivo base editing restores auditory function in a DFNA15 mouse model

Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition

Probing the crystallographic orientation of two-dimensional atomic crystals with supramolecular self-assembly

The correlation between serum sex hormone levels and clear cell renal cell carcinoma in male patients

Tumor-resident Malassezia can promote hepatocellular carcinoma development by downregulating bile acid synthesis and modulating tumor microenvironment

Controllable Thermal Rectification Realized in Binary Phase Change Composites

Table tennis motion recognition based on the bat trajectory using varying-length-input convolution neural networks

Study on the energy evolution mechanism of coal and rock with impact tendency under different strain rates

Structural insights into ribonucleoprotein dissociation by nucleocapsid protein interacting with non-structural protein 3 in SARS-CoV-2

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