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Showing 1–18 of 18 results
Advanced filters: Author: Renu George Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • To mark the 10th anniversary of Nature Reviews Cardiology, five of our Advisory Board members were invited to consider a topic within cardiology about which we know too little. The key opinion leaders from around the globe also suggest ways in which future research could be targeted to address the deficits in our understanding, with the aim of preventing cardiovascular disease, improving patient care, and reducing morbidity and mortality.

    • Ottavio Alfieri
    • Bongani M. Mayosi
    • Renu Virmani
    Reviews
    Nature Reviews Cardiology
    Volume: 11, P: 664-670

  • A draft map of the human proteome is presented here, accounting for over 80% of the annotated protein-coding genes in humans; some novel protein-coding regions, including translated pseudogenes, non-coding RNAs and upstream open reading frames, are identified.

    • Min-Sik Kim
    • Sneha M. Pinto
    • Akhilesh Pandey
    Research
    Nature
    Volume: 509, P: 575-581

  • The structural and temporal characteristics of atherosclerotic plaques differ between native coronary artery disease, vein-graft atherosclerosis, and in-stent neoatherosclerosis. In this Review, Yahagi et al. compare the shared and divergent morphological features, giving insight into the pathogenesis of atheroma formation, and provide an updated classification scheme for atherosclerotic lesions.

    • Kazuyuki Yahagi
    • Frank D. Kolodgie
    • Renu Virmani
    Reviews
    Nature Reviews Cardiology
    Volume: 13, P: 79-98

  • A large number of acute coronary syndrome (ACS) events originate from plaques with an intact fibrous cap (IFC). In this Review, Kanwar et al. provide an overview of the latest advances in our understanding of plaque morphology in ACS with IFC, reviewing contemporary data from multimodality imaging. They also discuss whether the use of such imaging might result in more effective management of patients with ACS.

    • Siddak S. Kanwar
    • Gregg W. Stone
    • Jagat Narula
    Reviews
    Nature Reviews Cardiology
    Volume: 13, P: 257-265

  • Arterial injury is an inevitable consequence of all interventional coronary procedures. In this Review, the authors explain the importance of a competent, functional endothelium for vascular health and describe the processes that are required for full endothelial recovery after arterial injury.

    • Fumiyuki Otsuka
    • Aloke V. Finn
    • Renu Virmani
    Reviews
    Nature Reviews Cardiology
    Volume: 9, P: 439-453

  • In this Review, Otsuka et al. describe how optical coherence tomography (OCT)—an intravascular imaging modality with high resolution—can be used to define various stages of plaque progression. The authors also highlight how OCT might be used in the identification of high-risk plaques vulnerable to rupture in patients with coronary disease, to enable pre-emptive interventional treatment, and how OCT might be used in the management of acute coronary syndromes.

    • Fumiyuki Otsuka
    • Michael Joner
    • Jagat Narula
    Reviews
    Nature Reviews Cardiology
    Volume: 11, P: 379-389

  • The Earth’s most stable quasi-satellite, Kamoʻoalewa, displays an extremely red reflectance spectrum typical of space weathering of lunar-like silicate material which raises the possibility that it is formed of material originating from the Moon

    • Benjamin N. L. Sharkey
    • Vishnu Reddy
    • Christian Veillet
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 2, P: 1-7

  • Quantitative assessment of plaque composition has not been possible with grayscale IVUS analysis—until now. Here König and coworkers examine intravascular ultrasonography-derived virtual histology, a method which can provide detailed analysis of plaque morphology, providing more information on the vulnerability of coronary plaques and, in turn, the risk of acute clinical events.

    • Andreas König
    • M Pauliina Margolis
    • Volker Klauss
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 5, P: 219-229