Nature Search

Sequence of reovirus haemagglutinin predicts a coiled-coil structure

Rhonda Bassel-Duby
Anula Jayasuriya
Bernard N. Fields
Research30 May 1985
Nature

Volume: 315, P: 421-423
Author Correction: HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

Feng Ye
Ying Chen
Q. Richard Lu
Amendments and Corrections16 Jul 2025
Nature Neuroscience

Volume: 28, P: 1810-1811
Correction: Corrigendum: Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

Congcong He
Michael C. Bassik
Beth Levine
Amendments and Corrections06 Nov 2013
Nature

Volume: 503, P: 146
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Jiandie Lin
Hai Wu
Bruce M. Spiegelman
Research15 Aug 2002
Nature

Volume: 418, P: 797-801
Mice without myoglobin

Daniel J. Garry
George A. Ordway
R. Sanders Williams
Research29 Oct 1998
Nature

Volume: 395, P: 905-908
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair

The adult mammalian heart has limited potential for regeneration and repair. Progress has been made in elucidating the cellular processes and regulatory mechanisms involved in heart growth and development, and this can be exploited to restore function in the injured adult heart.

Mei Xin
Eric N. Olson
Rhonda Bassel-Duby
Reviews10 Jul 2013
Nature Reviews Molecular Cell Biology

Volume: 14, P: 529-541
Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice

Adenine base editing successfully corrected a MYH7 pathogenic variant that causes hypertrophic cardiomyopathy in human cardiomyocytes and a mouse model of the disease, highlighting the potential of the approach to correct monogenic variants causing cardiac disease.

Andreas C. Chai
Miao Cui
Eric N. Olson
Research16 Feb 2023
Nature Medicine

Volume: 29, P: 401-411
The PD-1–PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration

Vargas Aguilar et al. report that the PD-1–PD-L1 checkpoint-inhibitor pathway is highly active in heart-resident and circulating immune cells of newborn mice and disruption of this pathway led to increased inflammation and pathogenic T cell activity, impairing regeneration.

Stephanie Vargas Aguilar
Miao Cui
Eric N. Olson
Research01 Mar 2024
Nature Cardiovascular Research

Volume: 3, P: 389-402
The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization

The nuclear envelope tethers chromatin to the nuclear periphery to control genome architecture. Here, the authors show that Net39 preserves the integrity and gene expression of muscle nuclei in mice, and it may contribute to the pathogenesis of Emery–Dreifuss muscular dystrophy.

Andres Ramirez-Martinez
Yichi Zhang
Eric N. Olson
ResearchOpen Access29 Jan 2021
Nature Communications

Volume: 12, P: 1-12
Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution

Researchers used single-nucleus RNA and ATAC sequencing to create an atlas of skeletal muscle development. They identified the gene programs and transcription factors that control muscle fiber development and maturation.

Matthieu Dos Santos
Akansha M. Shah
Eric N. Olson
ResearchOpen Access19 Jul 2023
Nature Communications

Volume: 14, P: 1-14
Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance

Following injury, cells in regenerative tissues can regrow, but how they adapt to injury conditions to regenerate the tissue is unclear. Here the authors identify a stress-responsive and cardioprotective factor Nrf1 that is critical for neonatal heart regeneration.

Miao Cui
Ayhan Atmanli
Eric N. Olson
ResearchOpen Access06 Sept 2021
Nature Communications

Volume: 12, P: 1-15
In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse

Dystrophin-deficient mice are used to test corrective strategies for Duchenne muscular dystrophy, but evaluation of dystrophin expression requires collection of tissue samples from specific muscles and time points. Here, the authors generate mice in which dystrophin expression is coupled to luciferase, and show that bioluminescence allows non-invasive monitoring of dystrophin expression following genome editing.

Leonela Amoasii
Hui Li
Eric N. Olson
ResearchOpen Access04 Oct 2019
Nature Communications

Volume: 10, P: 1-8
Heart repair by reprogramming non-myocytes with cardiac transcription factors

A combination of four transcription factors, GATA4, HAND2, MEF2C and TBX5, can reprogram fibroblasts into cardiac-like myocytes in vitro and in vivo; expression of these factors ameliorated cardiac function in mice that had suffered myocardial infarction.

Kunhua Song
Young-Jae Nam
Eric N. Olson
Research13 May 2012
Nature

Volume: 485, P: 599-604
Myomaker is a membrane activator of myoblast fusion and muscle formation

A muscle-specific membrane protein called myomaker is transiently expressed during myogenesis and is both necessary and sufficient to drive myoblast fusion in vivo and in vitro.

Douglas P. Millay
Jason R. O’Rourke
Eric N. Olson
Research17 Jul 2013
Nature

Volume: 499, P: 301-305
Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor

Francisco J. Naya
Brian L. Black
Eric N. Olson
Research15 Oct 2002
Nature Medicine

Volume: 8, P: 1303-1309
Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress

Norbert Frey
Tomasa Barrientos
Eric N Olson
Research14 Nov 2004
Nature Medicine

Volume: 10, P: 1336-1343
Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression

Alexandre Méjat
Francis Ramond
Laurent Schaeffer
Research13 Feb 2005
Nature Neuroscience

Volume: 8, P: 313-321
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

Previous work has suggested that the histone deacetylase HDAC1 promotes and canonical Wnt signaling antagonizes oligodendrocyte differentiation. Here, Ye et al. show that HDAC1/2 directly interferes with canonical Wnt signaling in oligodendrocyte precursors by competing with β-catenin for interaction with the transcriptional co-factor TCF7L2. TCF7L2 itself is shown to be crucial for oligodendrocyte development.

Feng Ye
Ying Chen
Q Richard Lu
Research07 Jun 2009
Nature Neuroscience

Volume: 12, P: 829-838
Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation

The authors show that reducing histone deacetylase 1 expression or activity in the nucleus accumbens increases global levels of histone acetylation but also increases histone methylation, leading to reduced cocaine-induced changes in behavior. This effect is mediated in part by decreased GABA_A receptor expression and decreased inhibitory tone on nucleus accumbens neurons.

Pamela J Kennedy
Jian Feng
Eric J Nestler
Research10 Mar 2013
Nature Neuroscience

Volume: 16, P: 434-440
A Twist2-dependent progenitor cell contributes to adult skeletal muscle

Liu et al. identify an interstitial progenitor cell, characterized by Twist2 expression, that is highly myogenic, forms type IIb/x myofibres and contributes to regeneration in adult skeletal muscle.

Ning Liu
Glynnis A. Garry
Eric N. Olson
Research20 Feb 2017
Nature Cell Biology

Volume: 19, P: 202-213
The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming

Garry et al. report that the histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to increase accessibility to core cardiac transcription factors, thus facilitating direct cardiac reprogramming.

Glynnis A. Garry
Svetlana Bezprozvannaya
Eric N. Olson
Research03 May 2021
Nature Cell Biology

Volume: 23, P: 467-475
Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development

Transcription of a long non-coding RNA, known as upperhand (Uph) located upstream of the HAND2 transcription factor is required to maintain transcription of the Hand2 gene by RNA polymerase, and blockade of Uph expression leads to heart defects and embryonic lethality in mice.

Kelly M. Anderson
Douglas M. Anderson
Eric N. Olson
Research26 Oct 2016
Nature

Volume: 539, P: 433-436
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

Acute exercise is shown to induce autophagy in skeletal muscle of fed mice, indicating a possible mechanism for the beneficial metabolic effects of exercise.

Congcong He
Michael C. Bassik
Beth Levine
Research18 Jan 2012
Nature

Volume: 481, P: 511-515
Therapeutic approaches for cardiac regeneration and repair

This Review discusses the advances in therapeutic approaches for cardiac repair and regeneration, including cell-based therapies as well as the use of secretory factors, such as microRNAs and exosomes, direct reprogramming strategies, and gene editing to control cardiac remodelling and redirect the adult heart to a regenerative state, and highlights the future prospects of preclinical and clinical trials of heart regeneration.

Hisayuki Hashimoto
Eric N. Olson
Rhonda Bassel-Duby
Reviews05 Jun 2018
Nature Reviews Cardiology

Volume: 15, P: 585-600

Search

Sequence of reovirus haemagglutinin predicts a coiled-coil structure

Author Correction: HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

Correction: Corrigendum: Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Mice without myoglobin

Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair

Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice

The PD-1–PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration

The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization

Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution

Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance

In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse

Heart repair by reprogramming non-myocytes with cardiac transcription factors

Myomaker is a membrane activator of myoblast fusion and muscle formation

Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor

Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress

Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation

A Twist2-dependent progenitor cell contributes to adult skeletal muscle

The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming

Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

Therapeutic approaches for cardiac regeneration and repair

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