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Showing 1–8 of 8 results
Advanced filters: Author: Riana D. Hunter Clear advanced filters

  • Analyses of mitochondrial genomes from populations in southern Africa provide evidence of a southern African origin of anatomically modern humans and a sustained occupation of the homeland before the first migrations of people appear to be driven by regional climate shifts.

    • Eva K. F. Chan
    • Axel Timmermann
    • Vanessa M. Hayes
    Research
    Nature
    Volume: 575, P: 185-189

  • A large-scale mouse study reveals that while existing epigenomic data detect many developmental enhancers, a substantial fraction is missed - highlighting the need for expanded resources to fully annotate enhancers genome-wide.

    • Brandon J. Mannion
    • Stella Tran
    • Len A. Pennacchio
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • MPRAs and in vivo transgenic mouse assays are two potentially complementary ways to assay the impact of noncoding variants. Here, authors find a strong and specific correlation between the assays in neural cells. Mouse assays also reveal pleiotropic effects not observed in MPRA.

    • Michael Kosicki
    • Dianne Laboy Cintrón
    • Nadav Ahituv
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Approximately a quarter of the human genome consists of gene deserts. Here, Abassah-Oppong et al. reveal the biological relevance, embryonic functions and underlying enhancer architecture of a genomic gene desert flanking the Shox2 transcription factor essential for limb, craniofacial and cardiac pacemaker development.

    • Samuel Abassah-Oppong
    • Matteo Zoia
    • Marco Osterwalder
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-24

  • Rajderkar et al. provide a genome-wide compendium of transcriptional enhancers active in human craniofacial development, along with single-cell resources for studies of mammalian craniofacial morphogenesis.

    • Sudha Sunil Rajderkar
    • Kitt Paraiso
    • Axel Visel
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Mutagenesis of 23 ultraconserved enhancers and examination of their activities in transgenic mouse reporter assays show that overall their regulatory properties are robust to mutation. Manipulation of endogenous loci in mice corroborates reporter assay data.

    • Valentina Snetkova
    • Athena R. Ypsilanti
    • Diane E. Dickel
    Research
    Nature Genetics
    Volume: 53, P: 521-528